Serum sex hormone levels after menopause and subsequent breast cancer

Journal of the National Cancer Institute
F BerrinoG Secreto

Abstract

High levels of androgens and estrogens have been reported to be associated with breast cancer. However, the multiplicity of factors that influence hormone levels and methodologic issues complicate the study of the relationship between steroid sex hormones and breast cancer. Using an improved study design, we assessed prospectively the relationship between the principal steroid sex hormones in serum and the subsequent occurrence of invasive breast cancer in postmenopausal women. Four thousand fifty-three healthy postmenopausal women aged 40-69 years, were enrolled from June 1987 through June 1992 in a prospective investigation of hormones and diet in the etiology of breast tumors (ORDET study) as part of a larger volunteer cohort of 10 788 premenopausal and postmenopausal women from Varese Province, northern Italy. At recruitment, blood samples were taken between 8:00 AM and 9:30 AM (after overnight fasting), and sera were preserved in -80 degree Celsius freezers. Women who had received hormone treatment in the 3 months prior to enrollment, who had bilateral ovariectomy, or who had a history of cancer or liver disease were not recruited. Twenty-five women in the final eligible cohort of postmenopausal women developed histologica...Continue Reading

Citations

Feb 10, 1998·International Journal of Cancer. Journal International Du Cancer·A MorabiaB Borisch
Nov 28, 2000·International Journal of Cancer. Journal International Du Cancer·P Vaittinen, K Hemminki
Aug 3, 2005·Virchows Archiv : an International Journal of Pathology·Cristina RivaVincenzo Eusebi
Jun 23, 2006·Journal of Cancer Research and Clinical Oncology·Andrei AnghelOana Mitrasca
Oct 16, 2007·Breast Cancer Research and Treatment·Ashok SubramanianKefah Mokbel
Jul 6, 2010·Journal of Cancer Survivorship : Research and Practice·Michelle E MeliskoHope S Rugo
Apr 30, 2005·The Journal of Steroid Biochemistry and Molecular Biology·P VihkoS Törn
May 24, 2005·The Journal of Steroid Biochemistry and Molecular Biology·Carlo CampagnoliFranco Berrino
May 15, 2002·Fertility and Sterility·Constantine DimitrakakisCarolyn A Bondy
Jan 15, 2002·European Journal of Obstetrics, Gynecology, and Reproductive Biology·I S SerinR Erez
Aug 1, 2000·Maturitas·J Marsden
May 26, 1999·Maturitas·D M GruberJ C Huber
Apr 12, 2001·Journal of Clinical Epidemiology·D S BuistN S Weiss
May 20, 1999·Baillière's Clinical Endocrinology and Metabolism·S R Davis, H G Burger
Mar 19, 2002·The Journal of Steroid Biochemistry and Molecular Biology·Dezhong J Liao, Robert B Dickson
Nov 19, 2003·The Journal of Steroid Biochemistry and Molecular Biology·Per Eystein Lønning
Dec 9, 2003·The Breast : Official Journal of the European Society of Mastology·R J BurcombeN Finer
May 23, 2001·Critical Reviews in Oncology/hematology·S ZurridaU Veronesi
Apr 15, 2008·Trends in Endocrinology and Metabolism : TEM·J MarsdenN P Sacks
Dec 23, 2003·Best Practice & Research. Clinical Endocrinology & Metabolism·W R Miller
Mar 28, 1998·Breast Cancer Research and Treatment·L Hilakivi-Clarke
Aug 15, 2000·Breast Cancer Research and Treatment·J ManjerJ Malina
Feb 27, 1997·The New England Journal of Medicine·Y ZhangD T Felson
Feb 15, 2001·The New England Journal of Medicine·M Clemons, P Goss
Feb 27, 2008·Proceedings of the National Academy of Sciences of the United States of America·Edward W BlankSatyabrata Nandi
Jul 31, 1998·The British Journal of Nutrition·S A BinghamA Coward
Dec 1, 2002·Nutrition Research Reviews·Julie A Lovegrove
Aug 12, 2005·Journal of the American College of Nutrition·Wen-Huey WuTzong-An Wang
Jun 4, 1997·Journal of the National Cancer Institute·E L WynderG Blackburn
Jun 13, 1998·Journal of the National Cancer Institute·G A Colditz
Sep 10, 1998·Journal of the National Cancer Institute·S E HankinsonF E Speizer
Mar 2, 1999·Journal of the National Cancer Institute·J F DorganR N Hoover
Jun 21, 2001·Journal of the National Cancer Institute·J M ZmudaUNKNOWN Study of Osteoporotic Fractures Research Group
Jul 19, 2001·Journal of the National Cancer Institute·V PalaF Berrino
Apr 18, 2002·Journal of the National Cancer Institute·T KeyUNKNOWN Endogenous Hormones and Breast Cancer Collaborative Group
Aug 21, 2003·Journal of the National Cancer Institute·T J KeyUNKNOWN Endogenous Hormones Breast Cancer Collaborative Group
Dec 17, 2004·Journal of the National Cancer Institute·Stacey A MissmerSusan E Hankinson
Jun 12, 2008·Journal of the National Cancer Institute·Eva S SchernhammerPaola Muti
Mar 7, 2009·Menopause : the Journal of the North American Menopause Society·Charles E WoodJ Mark Cline

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