Serum sex hormone levels are related to breast cancer risk in postmenopausal women

Environmental Health Perspectives
J F DorganA Schatzkin

Abstract

We conducted a nested case-control study to prospectively evaluate the relationship of serum estrogens and androgens to risk of breast cancer in postmenopausal women. From 1977 to 1987, 3375 postmenopausal women free of cancer and not taking replacement estrogens donated blood to the Breast Cancer Serum Bank in Columbia, Missouri. Of these, 72 were subsequently diagnosed with breast cancer. For each case, two controls matched on age and date and time of day of blood collection were selected using incidence density matching. The median age of subjects at blood collection was 62 years; the time from blood collection to diagnosis ranged from less than 1 to 9.5 years with a median of 2.9 years. Risk of breast cancer was positively and significantly associated with serum levels of estrogens and androgens. Compared to women in the lowest quartile, those in the highest quartile for non-sex hormone-binding globulin (non-SHBG) bound (bioavailable) estradiol had a relative risk of 5.2 (95% confidence interval [CI] = 1.5-18.5) and those in the highest quartile for testosterone had a relative risk of 6.2 (95% CI = 2.0-19.0). Our results lend considerable support to the hypothesis that serum concentrations of estrogens and androgens are rel...Continue Reading

References

Jun 1, 1992·American Journal of Epidemiology·C F GarlandK T Khaw
Mar 1, 1987·The Journal of Clinical Endocrinology and Metabolism·C LongcopeC C Johnston
May 1, 1987·American Journal of Epidemiology·D K WysowskiH L Lau
Feb 1, 1995·Journal of the National Cancer Institute·P G TonioloB S Pasternack
Jan 1, 1993·Epidemiologic Reviews·J L Kelsey
Mar 6, 1996·Journal of the National Cancer Institute·F BerrinoG Secreto

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Citations

Aug 29, 1998·Environmental Health Perspectives·D L DavisA J Sasco
Mar 8, 2002·Environmental Health Perspectives·Edward R SauterEleftherios P Diamandis
Aug 1, 2000·Indian Journal of Clinical Biochemistry : IJCB·B K Sharma, A Ray
Nov 29, 2008·Surgery Today·Hajime KurodaShinji Itoyama
Apr 2, 2003·Bone·Marjolein van der KliftUNKNOWN Rotterdam Study
May 16, 2006·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·D Kritz-SilversteinJ Sandwell
Apr 17, 2007·Journal of Bioenergetics and Biomembranes·Erika CioneGiuseppe Genchi
Nov 4, 2000·Expert Opinion on Investigational Drugs·P E Lønning
Feb 24, 2016·Hormones & Cancer·Robert T ChattertonSeema A Khan
Dec 17, 2009·Annals of Epidemiology·Qi DaiWei Zheng
Jul 17, 2007·The Journal of Steroid Biochemistry and Molecular Biology·B Nicolás Díaz-ChicoJuan C Díaz-Chico
Apr 26, 2001·Journal of the American Dietetic Association·J R HebertL Clemow
Mar 15, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Roberta B Ness, Francesmary Modugno
Feb 13, 2001·Clinical Endocrinology·F WuI R Reid
Feb 24, 1998·Annals of the New York Academy of Sciences·D L DavisM Wolff
Jun 18, 2005·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·A Chambô-FilhoF E L Pereira
Jul 31, 2007·Future Microbiology·James S LawsonNoel J Whitaker
Mar 2, 2012·The Journal of Endocrinology·A J ConleyA D Nguyen
Jul 1, 2001·Indian Journal of Clinical Biochemistry : IJCB·A RayB K Sharma
Dec 20, 2017·Oncotarget·Avisek MajumderSuresh C Tyagi
Jan 31, 2006·Arquivos brasileiros de endocrinologia e metabologia·Angela M Spinola e Castro, Gil Guerra-Júnior
Aug 21, 2002·Breast Cancer Research and Treatment·Josie L FalanyCharles N Falany
Mar 9, 2021·Frontiers in Veterinary Science·Guillermo ValdiviaLaura Peña
Dec 23, 2003·Best Practice & Research. Clinical Endocrinology & Metabolism·W R Miller

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