Serum sickness-like reaction associated with cefazolin

BMC Clinical Pharmacology
Michael BrucculeriDavid Serur

Abstract

Although rare, serum sickness-like reactions have been documented to occur following the administration of many antibiotics. Cefazolin, a first generation cephalosporin, is a commonly prescribed antibiotic which is considered to be generally safe and well tolerated. There have been no prior reports linking this drug with sickness-like reactions. We report a probable case of serum sickness-like reaction following a single dose of cefazolin. A 23 year old man with no significant past medical history was admitted to undergo a laparoscopic donor nephrectomy as part of a living-related renal transplant. One gram of intravenous cefazolin was administered perioperatively. The surgery was completed without complication and the remainder of his hospital course was uneventful. Ten days following discharge the patient developed fevers, painful and swollen joints, and a cutaneous eruption overlying his trunk and extremities. There was no evidence of systemic vasculitis. These clinical findings were most consistent with a serum sickness-like reaction. A brief course of corticosteroids and antihistaminergic therapy was initiated, and complete resolution of the patient's symptoms followed. The Naranjo probability scale indicated that this adv...Continue Reading

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Citations

Jul 12, 2013·Paediatric Drugs·Kara Heelan, Neil H Shear
Apr 12, 2013·Primary Health Care Research & Development·Rachel PerryEdzard Ernst
May 18, 2010·Cutaneous and Ocular Toxicology·Joseph Gnanaraj, Muhammad Wasif Saif
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May 2, 2021·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Natalia Blanca-LopezJean-Christoph Caubet

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