Serum SIRT1 Is Associated with Frailty and Adipokines in Older Adults

The Journal of Nutrition, Health & Aging
Lina MaY Li

Abstract

Because frailty is a major health concern among older patients, identifying frailty-related biomarkers will help in the early detection and prevention of frailty. Thus, we aimed to determine the association between circulating levels of silent mating-type information regulation 2 homolog 1 (SIRT1) and frailty. We assessed circulating SIRT1 levels in 16 robust, 74 prefrail, and 40 frail older adults. Frailty was diagnosed based on the Fried phenotype. Circulating cytokine and adipokine (e.g., vaspin, adiponectin, and leptin) levels were assessed. Differences in SIRT1 levels among the three subject groups were compared; correlations of SIRT1 levels with physical function and adipokine and cytokine levels were analyzed. Serum SIRT1 levels were significantly higher among frail older adults than among robust ones. Older adults with slowness or weight loss had high SIRT1 levels. Serum SIRT1 levels negatively correlated with gait speed, even after adjustment for age and sex; age; and insulin, vaspin, and leptin levels; they correlated negatively with phospholipase A2 levels. High SIRT1 levels were observed in frail elderly patients and were correlated with decreased physical function. Insulin and adipokine levels might be the link bet...Continue Reading

References

Mar 17, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·L P FriedUNKNOWN Cardiovascular Health Study Collaborative Research Group
Feb 18, 2005·The Journal of Biological Chemistry·Shino NemotoToren Finkel
Nov 7, 2006·Nature·Joseph A BaurDavid A Sinclair
Jul 20, 2007·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Kenneth Rockwood, Arnold Mitnitski
Dec 12, 2007·Rejuvenation Research·Nicola FerraraAmelia Filippelli
Sep 8, 2010·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·David G Le CouteurRafael de Cabo
Jun 2, 2012·Nature Reviews. Drug Discovery·Joseph A BaurRafael de Cabo
May 22, 2013·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Ravi VaradhanJeremy Walston
Oct 12, 2013·Genes & Development·Leonard Guarente
Oct 29, 2013·Annual Review of Pharmacology and Toxicology·David A Sinclair, Leonard Guarente
Jan 11, 2014·BMC Geriatrics·Carmen-Lucia CurcioFernando Gomez
Dec 3, 2014·Clinica Chimica Acta; International Journal of Clinical Chemistry·Lina Ma, Yun Li
Jun 5, 2015·Respirology : Official Journal of the Asian Pacific Society of Respirology·Yajun WangBin Wu
Jul 3, 2015·Brain Research Bulletin·Lina MaYulan Wang
Apr 20, 2016·BMC Medical Genetics·Rong LinWangwei Cai
Mar 23, 2017·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Shajjia RaziDavid G Le Couteur
Nov 21, 2017·Journal of Neuroimmunology·Rui LiWei Qiu
Dec 29, 2017·Critical Reviews in Eukaryotic Gene Expression·Muhammad Imran Qadir, Sidra Anwar

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Citations

Apr 1, 2021·The Journal of Nutrition, Health & Aging·L MaP Chan
May 13, 2021·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Trine B OpstadIngebjørg Seljeflot

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