Abstract
The extracellular domain of klotho is cleaved and released into various extracellular fluids, such as blood, urine, and cerebrospinal fluid, as soluble α-klotho (sαKl). We measured sαKl in 53 hemodialysis patients and 20 healthy controls to examine its role in mineral metabolism. The sαKl level of the hemodialysis patients was 430 pg/ml (386 - 540 pg/ml, which was lower than that of healthy controls 740 pg/ml (550 - 913 pg/ml, p < 0.01). The serum sαKl level showed a positive correlation with serum phosphorus (P) (σ = 0.33, p = 0.014), while serum corrected Ca tended to be negatively correlated with sαKl (σ = -0.26, p = 0.06). Both parameters showed the same trends in healthy subjects. However, there was no significant association between serum sαKl and age (σ= 0.21, p = 0.14), intact PTH (σ = -0.08, p= 0.55), whole PTH (σ = -0.08, p = 0.59), or FGF23 (σ = -0.07, p = 0.62). Multiple regression analysis showed that P was independently associated with the serum sαKl levels (total adjusted R2 = 0.18, p = 0.02). The sαKl level was lower in hemodialysis patients than in healthy persons. Serum P level was independently associated with the serum sαKl level.
Citations
Jun 22, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Annemieke C HeijboerUNKNOWN NIGRAM consortium
May 15, 2013·Current Opinion in Nephrology and Hypertension·Hannes Olauson, Tobias E Larsson
Nov 28, 2012·BMC Nephrology·Tetsu AkimotoEiji Kusano
Feb 23, 2013·PloS One·Masashi KitagawaHirofumi Makino
Sep 17, 2013·PloS One·Kensaku ShibataNobukazu Ishizaka
Oct 23, 2012·Clinical Journal of the American Society of Nephrology : CJASN·Mengjing WangJing Chen
Sep 10, 2014·BMC Nephrology·Michishige OzekiNobukazu Ishizaka
Apr 25, 2014·Journal of Nephrology·Francesca LeoneRenzo Bonofiglio
Apr 16, 2015·International Journal of Endocrinology·Silverio RotondiSandro Mazzaferro
Oct 18, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Sarah L BarkerSachdev S Sidhu
Nov 26, 2015·International Journal of Endocrinology·Naoko Otani-TakeiDaisuke Nagata
May 16, 2015·Journal of the American Society of Nephrology : JASN·Ming Chang HuOrson W Moe
Oct 21, 2016·British Journal of Cancer·Amanpreet KaurAshani T Weeraratna
Mar 13, 2014·The Journal of Clinical Endocrinology and Metabolism·Alexandra ScholzeMartin Tepel
Apr 23, 2014·Nephrology·Sven-Jean TanNigel D Toussaint
Aug 13, 2014·Nephrology·Hsin-Hung LinChiu-Ching Huang
Jun 9, 2018·Calcified Tissue International·Yasuto ShikidaTakanori Shibata
Aug 21, 2018·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Minako WakasugiIchiei Narita