Serum soluble CD25 as a risk factor of renal impairment in systemic lupus erythematosus - a prospective cohort study

Lupus
R J ZhangZ G Li

Abstract

Objective Serum soluble CD25 (sCD25) could be used as a biomarker for disease activity in conditions associated with T-cell activation including various autoimmune diseases. This study aimed to explore the role of sCD25 as an indicator of disease activity and organ involvement in patients with systemic lupus erythematosus (SLE). Methods Serum samples were collected from 107 SLE patients and 92 age-matched healthy controls (HCs). All patients were followed up for 24 weeks, and sCD25 was measured by enzyme-linked immunosorbent assay. Clinical and laboratory data were recorded at baseline and then every two weeks until week 24. The Systemic Lupus Erythematosus Disease Activity Index-2000 (SLEDAI)-2K was adopted for assessing disease activity at all visits. Results Serum sCD25 levels were significantly increased in SLE patients compared to those in HCs ( p < 0.001). More patients in the high-sCD25 group had lupus nephritis, arthritis and vasculitis ( p = 0.010, p = 0.023 and p = 0.042, respectively). SLEDAI-2K, erythrocyte sedimentation rate, C-reactive protein and 24-hour urinary protein excretion were all associated with high levels of sCD25 ( p < 0.001, p = 0.002, p = 0.038 and p = 0.029, respectively). During the 24-week follow...Continue Reading

References

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Citations

Feb 6, 2019·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Miao ShaoZhanguo Li
Feb 26, 2021·Journal of Autoimmunity·Aikaterini ThanouMelissa E Munroe
Jul 25, 2021·International Journal of Molecular Sciences·James Greenan-BarrettCoziana Ciurtin
Jun 17, 2021·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Laura E MartínezMarta Epeldegui

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Methods Mentioned

BETA
ESR

Software Mentioned

SPSS
SPSS Statistical Package for the Social Sciences

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