Serum Soluble Vascular Cell Adhesion Molecule-1 Overexpression Is a Disease Marker in Patients with First-Time Diagnosed Antinuclear Antibodies: A Prospective, Observational Pilot Study

BioMed Research International
Mara Oleszowsky, Matthias F Seidel

Abstract

Antinuclear antibodies (ANA) serve as screening tests for connective tissue diseases but have low specificity. In this pilot study, we aimed to identify patients with first-time positive ANA and musculoskeletal complaints and correlate serum soluble vascular adhesion molecules as biomarkers. Prospective, observational study with 100 ANA-positive patients, comparing them to age- and gender-matched healthy controls (HC, n = 75), was conducted. Serum levels of soluble intercellular adhesion molecule-1 (sICAM-1), endothelial-leukocyte adhesion molecule-1 (sELAM-1), and vascular cell adhesion molecule-1 (sVCAM-1) were measured. A subgroup of patients with systemic sclerosis (SSc) treated with immunosuppressants was followed over 10 months. Patients belonged to three main entities: rheumatoid arthritis (RA, n = 32), collagen diseases (CD, n = 56) also including systemic sclerosis (SSc, n = 11), and other autoimmune diseases (n = 12). sICAM-1 was similar among groups. sELAM-1 was elevated by 1.9-fold in only in SSc. sVCAM-1 was elevated by 3.1-fold in RA and by 3.3-fold in CD and in other autoimmune diseases by 3.4-fold. Seven SSc patients with immunosuppression had a 2.7-fold increased sVCAM-1 at baseline and reached the levels of he...Continue Reading

References

Jan 1, 1991·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·D SeronD O Haskard
Nov 1, 1995·British Journal of Rheumatology·C P DentonC M Black
Feb 1, 1996·Seminars in Arthritis and Rheumatism·R W McMurray
Jun 1, 1997·European Journal of Oral Sciences·M CuidaR Jonsson
May 15, 2002·Annals of the Rheumatic Diseases·C VitaliUNKNOWN European Study Group on Classification Criteria for Sjögren's Syndrome
Apr 18, 2003·Seminars in Arthritis and Rheumatism·Marco Matucci CerinicF Marongiu
Apr 30, 2003·Arthritis Research & Therapy·Khanh T Ho, John D Reveille
Aug 30, 2005·Annals of the New York Academy of Sciences·R BecvárL Pourová
Mar 30, 2006·Current Rheumatology Reports·Laura K Hummers
Mar 11, 2008·Rheumatic Diseases Clinics of North America·Bashar Kahaleh
Jul 12, 2008·Autoimmunity Reviews·Martial KoenigJean-Luc Senécal
Apr 14, 2010·Biomarkers in Medicine·Susan V Castro, Sergio A Jimenez
Mar 5, 2013·The Journal of Rheumatology·Alberto SulliMaurizio Cutolo
Dec 30, 2014·Journal of Global Infectious Diseases·John Victor PeterGeorge M Varghese

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Citations

Mar 4, 2021·Journal of Nanoscience and Nanotechnology·Giorgia AilunoGabriele Caviglioli

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Methods Mentioned

BETA
pharmacotherapy
ELISA
ESR

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