PMID: 9553983Apr 29, 1998Paper

Serum specific-IgE antibodies to peptides detected in a casein hydrolysate formula

Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology
K M Hoffman, H A Sampson

Abstract

Up to 2.5% of infants are affected by cow milk hypersensitivity in the first two years of life, although most of these children will "outgrow" their reactivity within 2-3 years. Extensively hydrolyzed ("hypoallergenic") cow milk-based formulae are often recommended as a substitute formula and are generally well tolerated. However, a small minority of cow milk-allergic children experience allergic reactions to the hypoallergenic formulae as well. Utilizing inhibition-ELISAs and sera from patients with IgE-mediated cow milk allergy, we have identified residual protein fractions less than 20 kD in several of the extensively hydrolyzed cow milk-based formulae. Although many of the cow milk allergic children had positive skin prick tests [SPT] to one of the hydrolysate formulae (Nutramigen), the positive skin test result generally did not correlate with clinical reactivity, although the negative predictive value of the negative SPT was excellent. Children with IgE-mediated cow milk allergy and a positive skin prick test to the hypoallergenic formula should probably receive their first dose of the formula in a medical setting so that appropriate therapy can be administered in the unlikely event of an allergic reaction.

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Citations

Dec 19, 2002·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Alessandro FiocchiLuigi Terracciano
Feb 25, 2000·Allergy·C NilssonB Härfast
Dec 1, 2010·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·C DupontUNKNOWN Comité de nutrition de la Société française de pédiatrie
Sep 16, 2015·Revista paulista de pediatria : orgão oficial da Sociedade de Pediatria de São Paulo·Jon A Vanderhoof
Oct 22, 2016·Journal of Pediatric Gastroenterology and Nutrition·Jon VanderhoofDelphine de Boissieu
Feb 27, 2004·International Journal of Food Sciences and Nutrition·Luz María de Regil, Ana María Calderón de la Barca
Jul 13, 2000·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·H FrisnerV Barkholt
Oct 26, 2000·Journal of Dairy Science·A Rosendal, V Barkholt
Jul 13, 2005·International Journal of Food Sciences and Nutrition·Ana María Calderón De La BarcaJosé Alberto López-Díaz
Mar 25, 2014·Allergologia et immunopathologia·N SantosM Morais-Almeida

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