Serum stability of peptides

Methods in Molecular Biology
Håvard Jenssen, Stein Ivar Aspmo

Abstract

Hospitals worldwide have lately reported a worrying increase in the number of isolated drug-resistant pathogenic microbes. This has to some extent fueled at least academic interest in design and development of new lead components for novel drug design. Much of this interest has been focused on antimicrobial peptides and peptides in general, primarily due to their natural occurrence and low toxicity. However, issues have been raised regarding the stability of peptide therapeutics for systemic use. The focus of this chapter is assays for measuring peptide stability in the presence of serum, both in vitro and in vivo.

Citations

Sep 23, 2016·Future Medicinal Chemistry·Xiayang XieYong Teng
Nov 5, 2016·Journal of Medicinal Chemistry·Sebastian BandholtzCarsten Grötzinger
Nov 8, 2016·Scientific Reports·Deepika MathurGajendra P S Raghava
Apr 27, 2017·Molecular Pharmaceutics·Lucas L BenninkS Michael Yu
Mar 17, 2017·Chembiochem : a European Journal of Chemical Biology·Aleksandra Balliu, Lars Baltzer
Jun 21, 2017·International Journal of Pharmaceutics·Xi-Rui ZhouShi-Zhong Luo
Nov 28, 2013·Pharmaceuticals·Wataru Aoki, Mitsuyoshi Ueda
Mar 8, 2018·Natural Product Reports·Jacob RodriguezMaciej A Walczak
Oct 21, 2017·Chemical Biology & Drug Design·Tyrslai M WilliamsSeetharama D Jois
Dec 6, 2014·Chembiochem : a European Journal of Chemical Biology·Susanne N WalkerBrian R McNaughton
Feb 28, 2019·Journal of Peptide Science : an Official Publication of the European Peptide Society·Rachna AnejaIrwin Chaiken
Jul 19, 2019·Journal of Peptide Science : an Official Publication of the European Peptide Society·Clara Pérez-PeinadoDavid Andreu
Mar 31, 2016·Journal of Peptide Science : an Official Publication of the European Peptide Society·Oliwia FrączakAleksandra Olma
Oct 24, 2019·Journal of Peptide Science : an Official Publication of the European Peptide Society·Isabel Cristina Chica AcevedoVani Xavier Oliveira
Aug 20, 2020·Journal of Peptide Science : an Official Publication of the European Peptide Society·Luana PalazziLaura Cendron
Sep 19, 2020·Chemical Biology & Drug Design·Pravin ParajuliSeetharama Jois
May 31, 2020·Genome Biology·Pedro PatraquimJuan-Pablo Couso
Jun 19, 2014·The Journal of Pharmacology and Experimental Therapeutics·Tatjana MomicPhilip Lazarovici
Jun 29, 2017·Scientific Reports·Noah KastelowitzHang Yin
Feb 13, 2018·Journal of Peptide Science : an Official Publication of the European Peptide Society·Sandeep PallerlaSeetharama D Jois
May 10, 2020·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Sven H HausnerJulie L Sutcliffe
May 19, 2012·PloS One·Sebastian BandholtzCarsten Grötzinger
Mar 20, 2020·Biomacromolecules·Philip Maximilian KnaffVolker Mailänder
Jul 12, 2017·Journal of Bioscience and Bioengineering·Lin WangXue-Long Sun
Apr 4, 2021·International Journal of Molecular Sciences·Damian NeubauerWojciech Kamysz
Jun 8, 2021·RSC Medicinal Chemistry·Ruchika GoyalVibin Ramakrishnan
Nov 5, 2011·Journal of the American Chemical Society·Daniel A Ryan, Julius Rebek
Aug 17, 2019·Journal of the American Chemical Society·Paul M LevineMatthew R Pratt

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