Serum sterol profiling reveals increased cholesterol biosynthesis in childhood obesity

The Journal of Steroid Biochemistry and Molecular Biology
Hyun-Hwa SonMan Ho Choi

Abstract

Quantitative sterol profiling in obese children and their clinical implications have not been fully investigated. The aim of study was to evaluate the metabolic changes in serum cholesterol and its precursors and metabolites, and their associations with clinical characteristics of childhood obesity. A total of 253 children aged 6-14 years (72 obese, 39 overweight, and 72 normal controls; 147 girls and 106 boys) were recruited. Anthropometric indices, body composition, and fasting total lipid profiles were determined. Serum concentrations of 20 sterols, as their free fraction, were analyzed through gas chromatography-mass spectrometry-based metabolite profiling. There were no significant differences in total- and LDL-cholesterols between groups. Serum levels of the main cholesterol precursors, lanosterol (P<0.02) and lathosterol (P<0.0001), were significantly higher in obese children. In addition, they showed positive correlations with waist to hip ratio, body fat percent, and body fat mass. The metabolic ratios of lanosterol and lathosterol to cholesterol were also elevated (P<0.01 both), indicating the up-regulation of cholesterol biosynthesis with childhood obesity. In contrast, the absorption of plant sterols tended to show ...Continue Reading

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Citations

Apr 26, 2015·The Journal of Steroid Biochemistry and Molecular Biology·Hong Seog Seo, Man Ho Choi
Sep 2, 2016·Endocrine-related Cancer·Ju-Yeun MoonJayoung Kim
Nov 22, 2017·International Journal of Obesity : Journal of the International Association for the Study of Obesity·H SunX J Yang
Feb 2, 2019·Diabetes/metabolism Research and Reviews·Howard Chong Huat HoRaffaella Buzzetti
Dec 24, 2017·Clinica Chimica Acta; International Journal of Clinical Chemistry·Tamara GojkovicZorana Jelic-Ivanovic
Jun 14, 2021·The Journal of Steroid Biochemistry and Molecular Biology·Go Eun KwonMan Ho Choi
Nov 20, 2021·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Evangelos HandakasOliver Robinson

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