Serum surfactant protein A and D may be novel biomarkers of COVID-19 pneumonia severity

Atsushi SaitoHirofumi Chiba


Background: COVID-19 is currently undergoing a pandemic worldwide, including in Japan, and many lives have been lost. So, there is an urgent need to develop new biomarkers for estimating progression or prognosis of COVID-19 patient. Lung-specific serum biomarkers, SP-A, SP-D and KL-6 have been used clinically for diagnosis of interstitial lung disease (ILDs), but their use in COVID-19 has not been investigated. To determine whether serum levels of SP-A, SP-D and KL-6 correlate with the severity of COVID-19 as indicated by clinical symptoms and radiological findings. Methods: In a cohort of 46 consecutive COVID-19 patients, laboratory data including serum SP-A, SP-D and KL-6 concentrations of 82 blood samples were analyzed and compared between severe and non-severe cases. In addition, the disease severity as indicated by these markers and chest HRCT images were compared.Results: Serum SP-A was significantly elevated from the early stage of pneumonia. In addition, serum SP-A and SP-D were significantly higher in severe than in non-severe cases. KL-6 was also significantly higher in severe-cases, but its mean was below the cut-off level for ILDs. AUC and their cut-off levels to detect severe cases in patients with COVID-19 infecti...Continue Reading

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