Serum-synovial gradient data of normouricemic patients with history of gout and acute knee effusion

Clinical Rheumatology
A P RozinA Balbir-Gurman

Abstract

The etiology of arthritis episodes in normouricemic patients with gout is still unclear. We propose that the fluctuation in synovial urate level, as well as pH, ion strength, albumin, and globulin values relative to serum levels, could be involved in crystal formation. To assess serum-synovial gradient (SSG), the sera and synovial fluid (SF) of six normouricemic patients (men, age 48-79) with a history of gout (American College of Rheumatology criteria) and acute knee effusion were screened for uric acid, pH, osmolality (Osm), P/Ca, albumin, globulin, and SSG. Monosodium urate monohydrate (MSUM) crystals were determined by polarized light (PL). Infectious arthritis was ruled out via Gram staining and synovial fluid culture. Negative X-ray and PL microscopy results excluded chondrocalcinosis. Five patients (1-5) had inflammatory knee effusion (WBC >2,000/mm(3)), and one (patient 6) had noninflammatory knee effusion (600 WBC/mm(3)). MSUM crystals were found in the WBC of patient 1 only. He had tophaceous gout with normal serum uric acid levels and showed significant negative Osm and P and positive Ca SSG. Two crystal negative patients had severe negative pH SSG with alkaline synovial fluid, significant P/Ca SSG, and high positive...Continue Reading

References

Aug 1, 1975·Annals of the Rheumatic Diseases·W R Wilcox, A A Khalaf
Apr 1, 1977·Arthritis and Rheumatism·S L WallaceT F Yü
May 1, 1992·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M KamL Addadi
Sep 1, 1972·Kidney International·E W HolmesJ B Wyngaarden
Jan 26, 1994·JAMA : the Journal of the American Medical Association·D J McCarty
Jan 1, 1993·Nihon rinsho. Japanese journal of clinical medicine·I AkaokaS Fujimori
Feb 14, 1998·Annals of the Rheumatic Diseases·J A LoganP E McGill

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Citations

Feb 4, 2010·Clinical Rheumatology·Doron RimarItzhak Rosner
Jun 23, 2018·Biomedical Reports·Binit VaidyaShweta Nakarmi

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