Serum Tau Proteins as Potential Biomarkers for the Assessment of Alzheimer's Disease Progression.

International Journal of Molecular Sciences
Eunjoo NamKeun-A Chang

Abstract

Total tau (t-tau) and phosphorylated tau (p-tau) protein elevations in cerebrospinal fluid (CFS) are well-established hallmarks of Alzheimer's disease (AD), while the associations of serum t-tau and p-tau levels with AD have been inconsistent across studies. To identify more accessible non-invasive AD biomarkers, we measured serum tau proteins and associations with cognitive function in age-matched controls (AMC, n = 26), mild cognitive impairment group (MCI, n = 30), and mild-AD group (n = 20) according to the Mini-mental State Examination (MMSE), Clinical Dementia Rating (CDR), and Global Deterioration Scale (GDS) scores. Serum t-tau, but not p-tau, was significantly higher in the mild-AD group than AMC subjects (p < 0.05), and there were significant correlations of serum t-tau with MMSE and GDS scores. Receiver operating characteristic (ROC) analysis distinguished mild-AD from AMC subjects with moderate sensitivity and specificity (AUC = 0.675). We speculated that tau proteins in neuronal cell-derived exosomes (NEX) isolated from serum would be more strongly associated with brain tau levels and disease characteristics, as these exosomes can penetrate the blood-brain barrier. Indeed, ELISA and Western blotting indicated that ...Continue Reading

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Citations

Dec 1, 2020·Journal of Alzheimer's Disease : JAD·Ivan KoychevHeinz Holling
Jan 16, 2021·Scientific Reports·Shinwoo KangKeun-A Chang
Feb 20, 2021·Clinical Interventions in Aging·Tao JinYaxing Gui

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Methods Mentioned

BETA
enzyme-linked immunosorbent assays
ELISA
transmission electron microscopy
transgenic
genotyping
electrophoresis

Software Mentioned

Graph Pad Prism
GraphPad
ImageJ
Malvern Panalytical
NTA

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