PMID: 2491611Jan 1, 1989Paper

Serum testosterone (T) levels in BALB/cByJ and BALB/cJ substrain mice: potential relationship with differential susceptibility to experimental allergic orchitis (EAO)

Autoimmunity
R SteenstraC Teuscher

Abstract

BALB/cByJ substrain mice are highly susceptible to the induction of EAO whereas BALB/cJ mice are resistant. BALB/cJ mice have been reported to have elevated levels of serum T, which may account for disease resistance in light of its purported immunosuppressive effects. Serum T levels were determined by radioimmunoassay on 40 BALB/cByJ and 41 BALB/cJ age matched male mice. Our results indicate that the two substrains do not differ significantly from each other in their mean serum T levels (BALB/cByJ-4.50 ng/ml and BALB/cJ-3.16 ng/ml; p = 0.601) suggesting that the EAO resistant phenotype exhibited by BALB/cJ mice is not a result of the immunosuppressive effects of T.

References

Feb 1, 1975·The Journal of Experimental Medicine·R A Murgita, T B Tomasi
Apr 1, 1977·The Journal of Experimental Medicine·M OlssonE Ruoslahti
Aug 30, 1972·Nature: New Biology·P IványiM Micková
Jul 1, 1965·The Journal of Clinical Endocrinology and Metabolism·R E MANCINIM NEMIROVSKY

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Citations

Nov 3, 2011·Reproduction : the Official Journal of the Society for the Study of Fertility·Niranjan ReddySandeep Goel

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