Serum thrombomodulin level relates to the clinical course of disseminated intravascular coagulation, multiorgan dysfunction syndrome, and mortality in patients with sepsis

Critical Care Medicine
Shu-Min LinHan-Pin Kuo

Abstract

To determine serum concentrations of thrombomodulin, the marker of endothelial injury, in patients with sepsis-induced disseminated intravascular coagulation and multiple organ dysfunction syndrome and to investigate the independent association between this marker and the development of disseminated intravascular coagulation, multiple organ dysfunction syndrome, and mortality. A prospective cohort study. A 37-bed intensive care unit of a tertiary care hospital. One hundred consecutive patients with sepsis. Serum thrombomodulin concentrations and the development of disseminated intravascular coagulation and multiple organ dysfunction syndrome were determined in patients on days 1 and 3 of sepsis. These data were used to determine an association between day 1 thrombomodulin concentrations and development of disseminated intravascular coagulation, multiple organ dysfunction syndrome, and mortality during intensive care unit stay. These connections were determined by the Cox proportional hazards model and plotting of receiver operating characteristic curves. Day 1 serum concentrations of thrombomodulin were higher in patients with disseminated intravascular coagulation (11.1 +/- 1.0 vs. 5.3 +/- 0.5 ng/mL; p < .0001) or multiple org...Continue Reading

References

Jul 1, 1990·Journal of Leukocyte Biology·P A Ward, J Varani
Dec 1, 1985·The Journal of Clinical Investigation·H Ishii, P W Majerus
Aug 1, 1995·Intensive Care Medicine·J BoldtG Hempelmann
Jun 1, 1996·American Journal of Respiratory and Critical Care Medicine·N HasegawaT A Raffin
Aug 19, 1999·The New England Journal of Medicine·M Levi, H Ten Cate
Mar 10, 2001·The New England Journal of Medicine·G R BernardUNKNOWN Recombinant human protein C Worldwide Evaluation in Severe Sepsis (PROWESS) study group
Aug 11, 2001·The New England Journal of Medicine·S N FaustR S Heyderman
May 11, 2002·Critical Care Medicine·Konrad ReinhartMichael Meisner
Apr 18, 2003·The New England Journal of Medicine·Greg S MartinMarc Moss
Oct 1, 2004·Journal of Thrombosis and Haemostasis : JTH·S MollG C White

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Citations

Aug 2, 2011·Seminars in Immunopathology·Edward M Conway
May 15, 2013·International Journal of Antimicrobial Agents·Evangelos J Giamarellos-Bourboulis
Apr 24, 2008·Critical Care Medicine·Shinichiro KurosawaGary T Kinasewitz
Dec 20, 2012·International Journal of Inflammation·Aline M Bernard, Gordon R Bernard
Feb 11, 2010·Critical Care : the Official Journal of the Critical Care Forum·Charalampos Pierrakos, Jean-Louis Vincent
Dec 4, 2012·Toxins·Chad L MayerDeborah J Stearns-Kurosawa
Feb 4, 2014·Journal of Translational Medicine·Alpha A FowlerRamesh Natarajan
Jun 3, 2014·Critical Care : the Official Journal of the Critical Care Forum·Kuan-Liang LiuPao-Hsien Chu
Jul 12, 2012·Expert Opinion on Emerging Drugs·Antigone Kotsaki, Evangelos J Giamarellos-Bourboulis
Aug 21, 2009·Journal of Veterinary Emergency and Critical Care·Barbara L Dallap Schaer, Kira Epstein
Apr 25, 2015·Critical Care : the Official Journal of the Critical Care Forum·Sisse Rye OstrowskiPär Ingemar Johansson
Feb 4, 2014·International Journal of Cardiology·Ting-Hsing ChaoYi-Heng Li
Oct 4, 2016·Intensive Care Medicine·Anders PernerTimothy Walsh
Nov 10, 2013·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Dunja M MihajlovicSnezana V Brkic
Jul 11, 2009·The Journal of International Medical Research·L ShengG-Y Jiang
Mar 18, 2010·Interactive Cardiovascular and Thoracic Surgery·Hernán Cohen AraziJuan Jose Badimon
Aug 31, 2018·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Ioannis VasileiadisAntonia Koutsoukou
May 27, 2011·Critical Care Medicine·Csaba Szabo, Brahm Goldstein
Mar 29, 2019·Biomarkers in Medicine·Dunja MihajlovicGorana Mitic
Apr 23, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Fiona A MartinPhilip M Cummins
Aug 19, 2017·International Journal of Adolescent Medicine and Health·Sasanka Kumar BaruaThekampadum Puthenveetil Rajeev
Apr 9, 2016·Critical Care Medicine·Kelly Genga, James A Russell
Aug 27, 2017·Critical Care : the Official Journal of the Critical Care Forum·Shinshu KatayamaJun Shima
Jul 30, 2019·Cancer Biomarkers : Section a of Disease Markers·Kunihiro AsanumaAkihiro Sudo
Mar 14, 2020·Critical Care Explorations·Shinshu KatayamaShin Nunomiya
May 16, 2017·Shock·Theis S ItenovUNKNOWN “Procalcitonin And Survival Study” study group
Oct 13, 2020·Frontiers in Immunology·Kanako Watanabe-KusunokiTatsuya Atsumi

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