Serum thrombopoietin compared with ZAP-70 and immunoglobulin heavy-chain gene mutation status as a predictor of time to first treatment in early chronic lymphocytic leukemia

Leukemia & Lymphoma
Stefano MolicaManlio Ferrarini

Abstract

In an effort to confirm previous reports we analyzed clinico-biological implications of increased serum levels of thrombopoietin (TPO) in a series of 71 previously untreated Binet stage A B-cell chronic lymphocytic leukemia (CLL) patients. Serum levels of TPO did not correlate with peripheral blood lymphocytosis (p = 0.928), Rai substages (p = 0.516), platelet count (p = 0.572), hemoglobin level (p = 0.228), LDH (p = 0.144) and beta2-microglobulin (p = 0.520). The same applied when correlation with ZAP-70 (p = 0.562), CD38 (p = 0.258) or mutational status of IgV(H) (p = 0.0794) were sought. The risk of disease-progression according to known and putative prognostic parameters was also evaluated as time to first treatment (TFT). The univariate Cox proportional hazard model demonstrated that the absence of IgV(H) mutational status (p = 0.0005) and ZAP-70-positivity (p = 0.02) were associated with a shorter TFT. In contrast, Kaplan-Meier estimates of TFT, plotted after setting as cut-off the median value for TPO (i.e., 46 pg/mL), failed to demonstrate any statistical difference between two groups (p = 0.342). Looking for cellular source of TPO we investigated the presence of TPO at gene expression level in 60 B-CLL patients belongi...Continue Reading

References

Dec 3, 1999·Clinical and Laboratory Haematology·A CeruttiC L Balduini
May 2, 2003·The New England Journal of Medicine·Marta CrespoEmili Montserrat
Feb 16, 2005·The Journal of Clinical Investigation·Bradley T MessmerNicholas Chiorazzi
Sep 1, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Luca AgnelliAntonino Neri
Feb 17, 2006·European Journal of Immunology·Giovanna CutronaManlio Ferrarini

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Citations

Feb 15, 2011·Leukemia & Lymphoma·Tamar Tadmor, Aaron Polliack
Jul 5, 2008·Blood Reviews·Femke Van BockstaeleJan Philippé
Aug 1, 2020·The Cochrane Database of Systematic Reviews·Nina KreuzbergerNicole Skoetz

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