Serum thrombospondin-1 is altered in patients with hemorrhagic fever with renal syndrome

Journal of Medical Virology
Zhengwen LiuNi Zhang

Abstract

Hemorrhagic fever with renal syndrome (HFRS) is a severe acute viral disease with pathological changes of impaired capillary and small vessels and thrombocytopenia. In this study, serum thrombospondin (TSP)-1 concentration in patients with HFRS was determined to explore its possible role in the pathogenesis of HFRS. The concentration of TSP-1 was measured using a competitive enzyme-linked immunoabsorbent assay. Significantly decreased levels of serum TSP-1 were observed in HFRS patients at febrile and hypotensive phases compared with those in the controls. The serum levels of TSP-1 in HFRS patients with more severe clinical types was reduced more profoundly than those in patients with milder clinical types at febrile and hypotensive phases, although the differences in TSP-1 were not significant. It was indicated that insufficient production or increased consumption of TSP-1, or both of these, may contribute to the impairment of capillary and small vessels and the development of hypotension at the early stage of HFRS, and the decreased degree may be associated with disease severity.

References

Jun 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·M L Iruela-ArispeH Sage
Sep 1, 1986·The Journal of Infectious Diseases·H X ChenS Y Gao
Sep 1, 1987·European Journal of Epidemiology·A AntoniadisS Daniel-Alexiou
Dec 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·R A MajackP Bornstein
Nov 1, 1984·The Journal of Clinical Investigation·L L Leung
Feb 1, 1994·Virus Research·M LiangC S Schmaljohn
Jul 1, 1993·In Vitro Cellular & Developmental Biology. Animal·V MorandiY J Legrand
Aug 1, 1996·Biochemical Society Transactions·M K PatelA D Hughes
Apr 1, 1997·Emerging Infectious Diseases·C Schmaljohn, B Hjelle
Nov 14, 1997·Arteriosclerosis, Thrombosis, and Vascular Biology·M K PatelA D Hughes
Feb 26, 1998·Cancer·Y YamashitaT Shirakusa
Oct 9, 2002·Proceedings of the National Academy of Sciences of the United States of America·Erika GeimonenErich R Mackow
Oct 12, 2002·Archives of Virology·I N GavrilovskayaE R Mackow
Oct 22, 2003·The Journal of Experimental Medicine·Virginie DoyenMarika Sarfati
Oct 22, 2004·Emerging Infectious Diseases·Franz Maximilian RascheLutz von Müller
Apr 19, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Natalya V NarizhnevaTatiana V Byzova
Apr 19, 2005·Journal of Medical Virology·Jonas HardestamAke Lundkvist
Nov 19, 2005·The Journal of Clinical Investigation·Charuhas V ThakarManoocher Soleimani
Sep 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Philippe GrimbertMarika Sarfati

❮ Previous
Next ❯

Citations

Aug 25, 2009·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Qunying HanZhengwen Liu
Aug 21, 2010·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Qunying HanNa Li
Jan 24, 2012·Matrix Biology : Journal of the International Society for Matrix Biology·David D RobertsJeffrey S Isenberg
Jan 15, 2014·Matrix Biology : Journal of the International Society for Matrix Biology·Natasha M RogersJeffrey S Isenberg
Aug 4, 2016·Frontiers in Microbiology·Svetlana F KhaiboullinaVincent C Lombardi
Jun 6, 2018·Frontiers in Cellular and Infection Microbiology·Xiude FanZhengwen Liu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.