Serum thymidine kinase activity in clinically healthy and diseased horses: a potential marker for lymphoma

The Veterinary Journal
S LarsdotterHenrik von Euler

Abstract

Serum thymidine kinase (sTK) activity is a tumour marker used as a prognostic indicator for lymphoma in humans, dogs and cats. The aim of this study was to evaluate the clinical utility of sTK as a biomarker for lymphoma in horses. Serum samples were collected from clinically normal horses (n = 37), horses with lymphoma (n = 23), horses with non-haematopoietic neoplasia (n = 9) and horses with inflammatory disease (n = 14). sTK was measured using a radioenzyme assay. A reference cut-off value of <2.7 U/L (mean + 2 standard deviations, SDs) was established using data from clinically normal horses. sTK activity (mean ± SD) was 26.3 ± 91.5 U/L (range 0.8-443 U/L) for horses with lymphoma, 2.3 ± 1.4 U/L (range 0.6-5.7 U/L) for horses with non-haematopoietic neoplasia and 1.5 ± 0.6 U/L (range 0.6-2.8 U/L) for horses with inflammatory disease. Horses with lymphoma had significantly higher sTK activity than horses without clinical signs of disease (P <0.01), horses with inflammatory disease (P <0.01) and horses with non-haematopoietic neoplasia (P <0.05). sTK activity is a potentially useful biomarker for equine lymphoma.

References

Jan 15, 1984·International Journal of Cancer. Journal International Du Cancer·J S GronowitzU Pettersson
Jan 1, 1995·Pharmacology & Therapeutics·E S Arnér, S Eriksson
Jan 1, 1993·Cancer Biotherapy·B M HanniganP G McKenna
Nov 15, 1997·The Journal of Veterinary Medical Science·N NakamuraA Hasegawa
Nov 27, 2002·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·D JagielskiS Winiarczyk
Nov 2, 2004·Journal of Veterinary Internal Medicine·Henrik von EulerStaffan Eriksson
Jun 17, 2009·The Journal of Small Animal Practice·F TaylorJ Dobson
Nov 7, 2009·The Journal of Small Animal Practice·S S TaylorJ M Dobson
Feb 10, 2011·Veterinary and Comparative Oncology·H von Euler, S Eriksson
Feb 3, 2012·Veterinary and Comparative Oncology·K E Flood-KnapikK U Sorenmo
Oct 19, 2012·Journal of Feline Medicine and Surgery·Samantha S TaylorHenrik P von Euler

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Citations

Jan 13, 2019·Journal of Veterinary Internal Medicine·Daniela LuethyAmy L Johnson
Mar 9, 2019·Current Hematologic Malignancy Reports·Jordan N Noble, Anjali Mishra

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