Serum thymulin in human zinc deficiency

The Journal of Clinical Investigation
A S PrasadM Dardenne

Abstract

The activity of thymulin (a thymic hormone) is dependent on the presence of zinc in the molecule. We assayed serum thymulin activity in three models of mildly zinc-deficient (ZD) human subjects before and after zinc supplementation: (a) two human volunteers in whom a specific and mild zinc deficiency was induced by dietary means; (b) six mildly ZD adult sickle cell anemia (SCA) subjects; and (c) six mildly ZD adult non-SCA subjects. Their plasma zinc levels were normal and they showed no overt clinical manifestations of zinc deficiency. The diagnosis of mild zinc deficiency was based on the assay of zinc in lymphocytes, granulocytes, and platelets. Serum thymulin activity was decreased as a result of mild zinc deficiency and was corrected by in vivo and in vitro zinc supplementation, suggesting that this parameter was a sensitive indicator of zinc deficiency in humans. An increase in T101-, sIg-cells, decrease in T4+/T8+ ratio, and decreased IL 2 activity were observed in the experimental human model during the zinc depletion phase, all of which were corrected after repletion with zinc. Similar changes in lymphocyte subpopulation, correctable with zinc supplementation, were also observed in mildly ZD SCA subjects. Inasmuch as t...Continue Reading

References

Oct 1, 1978·Annals of Internal Medicine·A S PrasadM R Fox
Oct 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·M DardenneJ F Bach
Jan 1, 1986·American Journal of Hematology·O F BallesterA S Prasad
Apr 1, 1985·Cellular Immunology·N Fabris, E Mocchegiani
Dec 1, 1971·Proceedings of the Society for Experimental Biology and Medicine·A S Prasad, D Oberleas
May 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·J M PléauJ F Bach
Jan 1, 1984·Arthritis and Rheumatism·B AmorJ F Bach
Jan 1, 1984·Cell and Tissue Research·B NabarraM Dardenne
Feb 14, 1984·Biochimica Et Biophysica Acta·L N GastinelJ F Bach
May 1, 1984·European Journal of Immunology·M DardenneJ F Bach
Sep 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·M DardenneJ F Bach

❮ Previous
Next ❯

Citations

Jul 1, 1995·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·A M AmarakoonR F Grimble
Nov 1, 1990·The Japanese Journal of Surgery·A OkadaS Lee
Jan 1, 1992·Biological Trace Element Research·J Neve
Apr 1, 1995·Aging : Clinical and Experimental Research·N Fabris, E Mocchegiani
Nov 4, 2011·Seminars in Immunopathology·James E Cassat, Eric P Skaar
Sep 12, 2006·Biogerontology·Wayne A MitchellRichard Aspinall
Oct 6, 2007·Biological Trace Element Research·G B Vega-RobledoG Rico-Rosillo
Sep 1, 1995·International Journal of Immunopharmacology·J W Hadden
Nov 1, 1994·General Pharmacology·G OztürkN M Bor
Jun 1, 1997·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·A S PrasadR H Mathog
Feb 13, 2001·Nutrition·A S Prasad
Jul 31, 1998·Nutrition·S Cunningham-Rundles, D H Lin
May 20, 1998·Baillière's Clinical Endocrinology and Metabolism·M E Keith, K N Jeejeebhoy
Jul 5, 2008·The British Journal of Nutrition·Rosalind S GibsonKenneth H Brown
Aug 31, 1999·The Proceedings of the Nutrition Society·M L Failla
Sep 6, 2000·Clinical and Experimental Immunology·R ConsoliniM Milani
Jan 1, 1993·The British Journal of Nutrition·C J BatesS C Longman
Jan 1, 1994·Nutrition Research Reviews·R S Gibson
Mar 1, 1991·The Proceedings of the Nutrition Society·P J Aggett
Mar 1, 1991·The Proceedings of the Nutrition Society·R P Thompson
Feb 16, 2010·Nutrition and Cancer·Ananda S PrasadOmer Kucuk
Jun 17, 1998·Journal of the American College of Nutrition·S NishiyamaI Matsuda
Oct 29, 1998·Journal of the American College of Nutrition·A S PrasadR H Mathog
Jan 1, 1993·Clinical and Experimental Dermatology·J F Arroyo, M L Cohen
Sep 1, 1994·Journal of Gastroenterology and Hepatology·H F Goode
Feb 22, 2003·BMJ : British Medical Journal·Ananda S Prasad
Jan 1, 1997·Annual Review of Nutrition·R A Goyer
Jan 5, 2012·The Journal of Clinical Investigation·Tatsuyoshi KawamuraShinji Shimada
Nov 20, 2010·Journal of Translational Medicine·Erica JohnMichael T Lotze
Jun 16, 2009·Immunity & Ageing : I & a·Hajo Haase, Lothar Rink
Jun 1, 1994·Environmental Health Perspectives·C T WalshP J Fraker
Oct 19, 2010·The Journal of Veterinary Medical Science·Keiko HamaguchiSoichi Imai
Jul 3, 2013·PLoS Neglected Tropical Diseases·Kamolwish LaoprasopwattanaRassamee Sangthong
Apr 4, 2008·Molecular Medicine·Ananda S Prasad
Mar 16, 2013·Advances in Nutrition·Ananda S Prasad
Jan 8, 2014·Iranian Red Crescent Medical Journal·Seyed Ali JavadmoosaviHanieh Raji
Sep 10, 2014·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Ananda S Prasad
Sep 28, 2014·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Ananda S Prasad
Jul 16, 2014·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Martina Maywald, Lothar Rink

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.