Serum thyroglobulin autoantibodies: prevalence, influence on serum thyroglobulin measurement, and prognostic significance in patients with differentiated thyroid carcinoma

The Journal of Clinical Endocrinology and Metabolism
C A SpencerJ T Nicoloff

Abstract

The prevalence of circulating thyroid autoantibodies (TgAb or antithyroid peroxidase) was increased nearly 3-fold in patients with differentiated thyroid cancers (DTC) compared with the general population (40% vs. 14%, respectively). Serum TgAb (with or without antithyroid peroxidase) was present in 25% of DTC patients and 10% of the general population. Serial postsurgical serum TgAb and serum Tg patterns correlated with the presence or absence of disease. Measurements of serum Tg were made in 87 TgAb-positive sera by a RIA and two immunometric assay (IMA) methods to study TgAb interference. TgAb interference, defined as a significant intermethod discordance (>41.7% coefficient of variation) between the Tg RIA and Tg IMA values relative to TgAb-negative sera, was found in 69% of the TgAb-positive sera. TgAb interference was characterized by higher Tg RIA vs. IMA values and was, in general, more frequent and severe in sera containing high TgAb concentrations. However, some sera displayed marked interference when serum TgAb was low (1-2 IU/mL), whereas other sera with very high TgAb values (>1000 IU/mL) displayed no interference. An agglutination method was found to be too insensitive to detect low TgAb concentrations (1-10 IU/mL...Continue Reading

Citations

Apr 1, 2010·Indian Journal of Surgical Oncology·Devendra A ChaukarMitali R Dandekar
Feb 13, 2013·International Journal of Proteomics·Jong Won Kim, Jinsam You
Feb 5, 2010·Acta Veterinaria Scandinavica·Andrea Vivian Alvarez-OxileyJean-François Beckers
Oct 30, 2008·Clinical Chemistry·Steven A Carr, Leigh Anderson
Mar 7, 2014·Annals of Surgical Oncology·Ioannis VasileiadisTheodore Karatzas
Sep 18, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Laurie L CarrRenato G Martins
Mar 2, 2013·The Journal of Clinical Endocrinology and Metabolism·Andrew N Hoofnagle, Mara Y Roth
Jul 1, 2005·Digestive Diseases and Sciences·Kenichi KomatsuShigeyuki Kawa
Jan 7, 2011·European Journal of Nuclear Medicine and Molecular Imaging·Frederik A VerburgHeribert Hänscheid
Dec 22, 2004·Current Treatment Options in Oncology·Jyotika K FernandesAnand K Sharma
Oct 8, 2013·Endocrinología y nutrición : órgano de la Sociedad Española de Endocrinología y Nutrición·Cristina Familiar CasadoSantiago Villanueva Curto
May 1, 2012·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Ravi K ViswanathanSameer K Mathur
May 17, 2011·Radiologic Clinics of North America·Amy E Cox, Shane O LeBeau
Jun 1, 2010·Otolaryngologic Clinics of North America·Amin Sabet, Matthew Kim
Jun 23, 2009·Journal of Immunological Methods·Andrew N Hoofnagle, Mark H Wener
May 23, 2009·Seminars in Oncology·Anita K YingSteven G Waguespack
Jan 22, 2009·Clinical Biochemistry·John Krahn, Tom Dembinski
Dec 2, 2008·Best Practice & Research. Clinical Endocrinology & Metabolism·Zélia Francis, Martin Schlumberger
Mar 8, 2008·Clinical Radiology·G-C RutherfordA O'Connor
Aug 4, 2007·Endocrinology and Metabolism Clinics of North America·D Robert Dufour
Aug 3, 2006·Surgical Oncology Clinics of North America·Roy Phitayakorn, Christopher R McHenry
Dec 5, 2013·ANZ Journal of Surgery·Sze Ling WongJonathan W Serpell
Dec 15, 2005·International Journal of Clinical Practice·P NixA P Coatesworth
Feb 6, 2014·Clinical Endocrinology·Stephanie Smooke-PrawMichael W Yeh
Jul 15, 2004·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·H M van SantenC van den Bos
Sep 9, 2006·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·A IervasiG C Zucchelli
Feb 7, 2006·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·P KjellmanG Wallin
May 26, 2004·Clinics in Laboratory Medicine·George G Klee

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Thyroiditis

Autoimmune thyroiditis is an inflammatory disease of thyroid gland due to autoimmune responses leading to lymphocytic infiltration of the gland. It is characterized by the presence of circulating thyroid antigen-specific T-cells and thyroid autoantibodies. Discover the latest research on autoimmune thyroiditis here.

Antibodies: Agglutination

Antibody-mediated agglutination is the clumping of cells in the presence of antibody, which binds multiple cells together. This enhances the clearance of pathogens. Find the latest research on antibody-mediated agglutination here.

Absence Epilepsy

Absence epilepsy is a common seizure disorder in children which can produce chronic psychosocial sequelae. Discover the latest research on absence epilepsies here.