PMID: 6407268Apr 1, 1983Paper

Serum thyroid hormones and blood folic acid during monotherapy with carbamazepine or valproate. A controlled study

Acta Neurologica Scandinavica
K D BentsenA Veje

Abstract

Studies investigating the influence of antiepileptic drugs on thyroid hormones usually have compared patients chronically treated with antiepileptic drugs to controls. To date, this type of designs has produced divergent results both with regard to individual drugs and individual thyroid hormones. The present study comprised 31 patients with newly diagnosed epilepsy, commencing treatment with either carbamazepine or valproate. T3, T4, FT4, FT3, rT3, TSH, T3 resin uptake and blood folic acid, were determined before and during antiepileptic monotherapy, thus making the patient his own control. During treatment with carbamazepine, a significant decrease in T4, FT4, FT3, rT3 and TBG was observed. Valproate caused a decrease in T4, FT4 and T3. Neither of the drugs caused any changes in blood folic acid concentrations or persistent increases in the TSH values. None of the patients developed overt symptoms of hypothyreoidism. Conceivable mechanisms underlying these hormonal changes are reviewed.

References

Dec 1, 1978·Scandinavian Journal of Clinical and Laboratory Investigation·K RootweltS I Johannessen
Aug 1, 1979·British Journal of Clinical Pharmacology·J OxleyA Richens
Apr 1, 1978·Annals of Internal Medicine·C T SawinF Azizi
Jun 17, 1978·British Medical Journal·P P YeoD C Evered
Jan 1, 1976·Clinical Pharmacokinetics·E F Hvidberg, M Dam
Jun 21, 1969·Lancet·E H ReynoldsI Chanarin
Oct 1, 1974·The Journal of Clinical Endocrinology and Metabolism·J M HansenK Siersbaek-Nielsen
Jan 1, 1973·Scandinavian Journal of Haematology·P Reizenstein, L Lund
Jun 1, 1970·The Journal of Clinical Investigation·P R LarsenR E Goldsmith
Sep 1, 1971·The Journal of Clinical Endocrinology and Metabolism·H GharibT Hockert
Mar 13, 1971·British Medical Journal·R HallB J Ormston
Feb 1, 1981·Acta Neurologica Scandinavica·R E StrandjordS I Johannessen
Mar 1, 1961·The Journal of Clinical Endocrinology and Metabolism·J H OPPENHEIMERJ W JAILER
Dec 1, 1976·British Journal of Clinical Pharmacology·J F Finucane, R S Griffiths

❮ Previous
Next ❯

Citations

Jan 1, 1985·Psychopharmacology·D R RubinowS Reichlin
Jan 1, 1994·Journal of Tongji Medical University = Tong Ji Yi Ke Da Xue Xue Bao·S Q ZhuZ Cai
Nov 25, 2005·European Journal of Clinical Pharmacology·M Strolin BenedettiF Tonner
Aug 3, 2001·Pediatric Neurology·A VerrottiF Chiarelli
Jul 5, 2001·The Australian and New Zealand Journal of Psychiatry·G S MalhiI Caterson
Dec 21, 1995·The New England Journal of Medicine·M I Surks, R Sievert
Oct 15, 2011·Clinical Neuropharmacology·Rami Bou Khalil, Sami Richa
Nov 6, 2008·European Journal of Endocrinology·Alberto VerrottiFrancesco Chiarelli
Oct 6, 2015·Expert Review of Clinical Pharmacology·Sherifa Ahmed Hamed
Jul 17, 2009·Pharmacological Reports : PR·Tomasz JakubusStanisław J Czuczwar
May 21, 2011·General Hospital Psychiatry·Young-Min ParkHeon-Jeong Lee
Nov 21, 2007·Pediatric Neurology·Manuel Castro-GagoJesús Eirís-Puñal
Jul 1, 1990·General Hospital Psychiatry·M D Hein, I M Jackson
Sep 20, 2005·Epilepsy Research·Sherifa A HamedHanan Omar
Apr 2, 2017·Seizure : the Journal of the British Epilepsy Association·Fu-Yuan ShihMeng-Han Tsai
Jan 11, 2002·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·S KochenS Oddo
Sep 9, 2018·Acta Neurologica Scandinavica·Margret Jona EinarsdottirHelga Agusta Sigurjonsdottir
Sep 14, 2007·Acta Neurologica Scandinavica·J Simko, J Horacek
Mar 1, 1991·Acta Psychiatrica Scandinavica·A BocchettaM Del Zompo
Oct 1, 1989·Acta Paediatrica Japonica; Overseas Edition·S KodamaK Koderazawa
Aug 1, 1995·Psychiatry and Clinical Neurosciences·M KimuraY Maeoka
Jan 1, 1992·Epilepsia·J I IsojärviV V Myllylä
Dec 2, 2005·Expert Opinion on Pharmacotherapy·Po W Wang, Terence A Ketter
Jul 29, 2008·Journal of Pediatric Endocrinology & Metabolism : JPEM·Alberto VerrottiFrancesco Chiarelli
Jan 10, 2003·Bipolar Disorders·F CassidyB J Carroll
Aug 1, 1985·Acta Neurologica Scandinavica·L Gram, K D Bentsen
Aug 1, 1984·Acta Neurologica Scandinavica·H DinesenM Dam
Apr 1, 1986·Biological Psychiatry·D R Rubinow

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.