Serum-to-urine renalase ratio and renalase fractional excretion in healthy adults and chronic kidney disease patients.

BMC Nephrology
Natalia SerwinBarbara Dołęgowska

Abstract

Renalase is a flavoprotein that plays a protective role in chronic kidney disease (CKD) and cardiovascular diseases. The secretion and way of action of this protein are still discussed. The aim of our study was to estimate the balance between serum and urine renalase in healthy individuals and CKD patients, using two parameters: fractional excretion (FE) and serum-to-urine renalase ratio (StURR). Our study involved 28 healthy volunteers and 62 patients with CKD in stages I to IV. The concentration of renalase in serum and urine was measured using an enzyme-linked immunosorbent assay (ELISA) kit (EIAab, Wuhan, China). We analyzed associations between renalase levels in urine and serum, and other parameters: sex, age, GFR, presence of hypertension, diabetes, and proteinuria, and determined the serum-to-urine renalase ratio and fractional excretion of renalase. Renalase and serum-to-urine ratio were significantly higher in CKD patients in comparison with the control group. Fractional excretion was lower in CKD patients but this difference did not reach the statistical significance (p = 0.092). Multivariate analysis performed in the CKD group showed, that from mentioned parameters, serum renalase was the only significant independen...Continue Reading

References

Apr 21, 2005·The Journal of Clinical Investigation·Jianchao XuGary V Desir
Sep 12, 2007·Molecular Biology Reports·Jian WangShu-Ping Zhang
Feb 16, 2008·Current Opinion in Nephrology and Hypertension·Gary V Desir
May 26, 2012·Journal of Cardiovascular Pharmacology and Therapeutics·A Baraka, S El Ghotny
Oct 12, 2012·PloS One·Feng WangNiansong Wang
Nov 7, 2012·Journal of the American Heart Association·Gary V DesirHeino Velazquez
Nov 28, 2012·Experimental and Therapeutic Medicine·Weihong JiangKan Yang
Jan 15, 2013·Journal of Hypertension·Janete Quelhas-SantosManuel Pestana
Feb 9, 2013·Journal of the American Society of Nephrology : JASN·H Thomas LeeGary V Desir
Aug 24, 2013·Journal of the American Chemical Society·Brett A BeaupreGraham R Moran
Feb 11, 2014·Journal of the American Society of Nephrology : JASN·Ling WangGary V Desir
Jul 26, 2014·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Agnieszka Rybi-SzumińskaAnna Wasilewska
Aug 26, 2014·Lipids in Health and Disease·Anna Gluba-BrzózkaJacek Rysz
Apr 24, 2015·PloS One·Ling WangGary V Desir
Apr 23, 2016·PloS One·Ellen P M van LoonJoost G J Hoenderop
Nov 28, 2017·The Korean Journal of Internal Medicine·Seon Ha BaekKi Young Na
Jul 30, 2018·Life Sciences·Katsuyuki TokinoyaKazuhiro Takekoshi

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA
urine collection

Software Mentioned

RNLS
STATISTICA

Related Concepts

Related Feeds

Cardiovascular Disorder in Diabetes

Diabetes is associated with an increased risk of cardiovascular disorders and heart failure. Discover the latest research here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.