Mar 29, 2020

Serum total bile acids associate with risk of incident type 2 diabetes and longitudinal changes in glucose related metabolic traits

Journal of Diabetes
Wen ZhuGuang Ning


Bile acids have been found related to changes in gut microbiota and multiple metabolic disorders, including type 2 diabetes (T2D). We aimed to prospectively investigate associations of serum total bile acids (TBA) with risk of incident T2D and longitudinal changes in glycemic traits. A community-based study was conducted at baseline in 2010, including 4968 non-diabetic participants aged ≥40 years followed up for average 4.3 years. Incident T2D was defined by using 1999 WHO criteria based on 75 g oral glucose tolerance tests. Multivariate Cox's proportional hazards regression was used to examine the association of serum TBA with incident T2D. Fasting and 2 h post-loading plasma glucose (FPG and 2 h-PPG), fasting serum insulin (FSI) were measured at baseline and follow-up. During 21 653.7 person-years' follow-up, 605 incident diabetes were obtained (incidence rate 2.8%). Comparing to quartile 1 of serum TBA, quartile 2, 3, and 4 was significantly associated with a 14.2%, 15.0%, and 31.4% higher risk of incident T2D (P = 0.029). Each 1-unit of log-TBA was associated with 0.034 mmol/L increase in FPG, 0.111 mmol/L in 2 h-PPG, 0.023 in log-FSI and 0.012 in log-HOMA-IR (all P ≤ 0.024). The association was attenuated after further adj...Continue Reading

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Mentioned in this Paper

2,3,6-trichlorobenzoic acid
Oral Glucose Tolerance Test
Metabolic Diseases
Diabetes Mellitus, Non-Insulin-Dependent
Homeostasis Model Assessment

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