Mar 29, 2020

Serum total bile acids associate with risk of incident type 2 diabetes and longitudinal changes in glucose related metabolic traits

Journal of Diabetes
Wen ZhuGuang Ning

Abstract

Bile acids have been found related to changes in gut microbiota and multiple metabolic disorders, including type 2 diabetes (T2D). We aimed to prospectively investigate associations of serum total bile acids (TBA) with risk of incident T2D and longitudinal changes in glycemic traits. A community-based study was conducted at baseline in 2010, including 4968 non-diabetic participants aged ≥40 years followed up for average 4.3 years. Incident T2D was defined by using 1999 WHO criteria based on 75 g oral glucose tolerance tests. Multivariate Cox's proportional hazards regression was used to examine the association of serum TBA with incident T2D. Fasting and 2 h post-loading plasma glucose (FPG and 2 h-PPG), fasting serum insulin (FSI) were measured at baseline and follow-up. During 21 653.7 person-years' follow-up, 605 incident diabetes were obtained (incidence rate 2.8%). Comparing to quartile 1 of serum TBA, quartile 2, 3, and 4 was significantly associated with a 14.2%, 15.0%, and 31.4% higher risk of incident T2D (P = 0.029). Each 1-unit of log-TBA was associated with 0.034 mmol/L increase in FPG, 0.111 mmol/L in 2 h-PPG, 0.023 in log-FSI and 0.012 in log-HOMA-IR (all P ≤ 0.024). The association was attenuated after further adj...Continue Reading

  • References27
  • Citations

References

  • References27
  • Citations

Citations

  • This paper may not have been cited yet.

Mentioned in this Paper

2,3,6-trichlorobenzoic acid
Oral Glucose Tolerance Test
Metabolic Diseases
Plasma
SRGN
Glucose
Diabetes Mellitus, Non-Insulin-Dependent
Follow-up
Fasting
Homeostasis Model Assessment

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Autism: Motor Learning

A common feature of autism spectrum disorder (ASD) is the impairment of motor control and learning, consistent with perturbation in cerebellar function. Find the latest research on ASD and motor learning here.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Sexual Dimorphism in Neurodegeneration

There exist sex differences in neurodevelopmental and neurodegenerative disorders. For instance, multiple sclerosis is more common in women, whereas Parkinson’s disease is more common in men. Here is the latest research on sexual dimorphism in neurodegeneration

Protein Localization in Disease & Therapy

Localization of proteins is critical for ensuring the correct location for physiological functioning. If an error occurs, diseases such as cardiovascular, neurodegenerative disorders and cancers can present. Therapies are being explored to target this mislocalization. Here is the latest research on protein localization in disease and therapy.

Genetic Screens in Bacteria

Genetic screens can provide important information on gene function as well as the molecular events that underlie a biological process or pathway. Here is the latest research on genetic screens in bacteria.

Head And Neck Squamous Cell Carcinoma

Squamous cell carcinomas account for >90% of all tumors in the head and neck region. Head and neck squamous cell carcinoma incidence has increased dramatically recently with little improvement in patient outcomes. Here is the latest research on this aggressive malignancy.

Artificial Intelligence in Cardiac Imaging

Artificial intelligence (ai) techniques are increasingly applied to cardiovascular (cv) medicine in cardiac imaging analysis. Here is the latest research.