Serum trace metal association with response to erythropoiesis stimulating agents in incident and prevalent hemodialysis patients

Scientific Reports
Michael E BrierMichael L Merchant

Abstract

Alterations in hemodialysis patients' serum trace metals have been documented. Early studies addressing associations levels of serum trace metals with erythropoietic responses and/or hematocrit generated mixed results. These studies were conducted prior to current approaches for erythropoiesis stimulating agent (ESA) drug dosing guidelines or without consideration of inflammation markers (e.g. hepcidin) important for regulation of iron availability. This study sought to determine if the serum trace metal concentrations of incident or chronic hemodialysis patients associated with the observed ESA response variability and with consideration to ESA dose response, hepcidin, and high sensitivity C-reactive protein levels. Inductively-coupled plasma-mass spectrometry was used to measure 14 serum trace metals in 29 incident and 79 prevalent dialysis patients recruited prospectively. We compared these data to three measures of ESA dose response, sex, and dialysis incidence versus dialysis prevalence. Hemoglobin was negatively associated with ESA dose and cadmium while positively associated with antimony, arsenic and lead. ESA dose was negatively associated with achieved hemoglobin and vanadium while positively associated with arsenic. ...Continue Reading

References

Dec 1, 1990·The Journal of Toxicological Sciences·L W Chang
Jun 1, 1990·Environmental Health Perspectives·R A Goyer
Sep 30, 1980·Biochemical and Biophysical Research Communications·R E CatalánM D Aragonés
Nov 1, 1981·American Journal of Hematology·C J DeurE P Frenkel
Jan 1, 1996·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·P C D'Haese, M E De Broe
Jan 10, 1997·The Journal of Biological Chemistry·G HuyerC Ramachandran
Jan 7, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·G R EhringM D Cahalan
Mar 21, 2002·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Raymond VanholderNorbert Lameire
Jan 7, 2004·Advances in Renal Replacement Therapy·Kamyar Kalantar-Zadeh, Joel D Kopple
Jan 20, 2004·Toxicology and Applied Pharmacology·Jianhua ZhaoMax Costa
Apr 20, 2004·Toxicology and Applied Pharmacology·Jianhua ZhaoMax Costa
Oct 19, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Steven Fishbane, Anatole Besarab
Mar 6, 2008·Kidney & Blood Pressure Research·Michael FöllerFlorian Lang
Mar 1, 1997·Trends in Endocrinology and Metabolism : TEM·E Tsiani, I G Fantus
Oct 9, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Brian D BradburyRaymond H Hakim
Nov 26, 2008·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Ajay K Singh
Apr 3, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Kamyar Kalantar-ZadehCsaba P Kovesdy
May 21, 2009·BMC Medicine·Marcello TonelliUNKNOWN Alberta Kidney Disease Network
Oct 8, 2009·Clinical Journal of the American Society of Nephrology : CJASN·Dana MiskulinFriedrich K Port
Nov 19, 2009·Neurotoxicity Research·Vanessa A FitsanakisMichael Aschner
Mar 6, 2010·Toxicology and Industrial Health·Amir Shokooh Saljooghi, S J Fatemi
Aug 6, 2010·Talanta·Regina de Carvalho Oliveira, Ricardo Erthal Santelli
Nov 5, 2010·The New England Journal of Medicine·Jonathan Himmelfarb, T Alp Ikizler
Dec 4, 2010·Journal of Pharmacological Sciences·Eiko TadaToshihiko Murayama
Nov 25, 2011·Hemodialysis International·Jennifer Cross, Andrew Davenport
Feb 22, 2012·Current Opinion in Chemical Biology·Jian-Xiang LiuZhu Chen
Jul 6, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Stephanie Thompson, Marcello Tonelli
Sep 1, 2012·Journal of the American Society of Nephrology : JASN·Jodie L Babitt, Herbert Y Lin
Sep 22, 2012·Seminars in Dialysis·David A Fendley, Richard A Ward
Feb 27, 2013·Advances in Chronic Kidney Disease·T Alp Ikizler
Mar 6, 2013·Environmental Health Perspectives·Marisa F NaujokasWilliam A Suk
Jul 3, 2013·Journal of Clinical and Diagnostic Research : JCDR·Subha Palaneeswari M Jothimalar
Sep 14, 2013·Journal of the American Society of Nephrology : JASN·Adam E GawedaMichael E Brier
Apr 24, 2014·Central European Journal of Urology·Mykola ProdanchukMykola Kulyzkiy
Apr 18, 2015·BMC Nephrology·Marcello TonelliUNKNOWN Alberta Kidney Disease Network

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