PMID: 1205274Oct 1, 1975Paper

Serum transaminase levels after experimental paracetamol-induced hepatic necrosis

Gut
M F DixonM S Losowsky

Abstract

The relationship between serum transaminase levels and the extent of paracetamol-induced liver necrosis has been investigated in the rat. Three methods of histological quantitation were used to assess of necrosis--arbitrary grading, point counting, and the image-analysis computer. Highly significant correlations were obtained between the three methods and all were found to be reproducible. A close correlation was found between the extent of hepatic necrosis and the serum ASAT and ALAT 24 hours after a large dose (4 g/kg) of paracetamol. Likewise, the mean grade of necrosis correlated reasonably well with the serum enzyme levels in the recovery phase at 36 and 72 hours, although the transaminase level for a given degree of necrosis was considerably lower at 72 hours than at 24 hours. These findings suggest that serum transaminase levels gives a reliable indication of the severity of hepatic necrosis if the time of ingestion of the paracetamol is known and taken into account.

References

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Citations

Oct 1, 1993·Pharmacology & Therapeutics·S H Thomas
Jan 1, 1980·The Western Journal of Medicine·B H Rumack, R G Peterson
Sep 1, 1977·Pharmacological Research Communications·J KelleherM S Losowsky
Jul 19, 2013·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·John MachSarah N Hilmer
Jul 21, 1976·Virchows Archiv. A, Pathological Anatomy and Histology·M LesnaO F James
Mar 6, 2007·The Veterinary Clinics of North America. Small Animal Practice·Sharon A Center
Sep 8, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Naohisa KuriyamaAna J Coito
May 26, 2017·Journal of Veterinary Internal Medicine·K DirksenH Fieten
Jan 1, 1981·The Journal of International Medical Research·A N HamlynP Crome
Jan 1, 1976·The Journal of International Medical Research·J KelleherM S Losowsky

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