Serum transforming growth factor-beta levels depend on allergen exposure in allergic rhinitis

International Archives of Allergy and Immunology
Giorgio CiprandiG Marseglia

Abstract

Allergic rhinitis (AR) is characterized by inflammation sustained by dysregulated immune response. T-regulatory cells are involved in AR pathogenesis, mainly producing IL-10 and transforming growth factor (TGF)-beta. Indeed, there is a functional and allergen-specific defect of T-regulatory cells in AR. However, there are no data about the influence of allergen exposure on TGF-beta serum levels. Therefore, the aim of this preliminary study was to evaluate TGF-beta serum levels in patients with seasonal AR. Patients were evaluated either outside the pollen season and after 1 preseasonal sublingual immunotherapy (SLIT) course (38 subjects) or during the pollen season (57 subjects). All patients were allergic to Parietaria and/or grasses alone. TGF-beta was measured by a commercially available kit. Symptoms, drug use and eosinophils were evaluated.Serum allergen-specific IgG and IgA levels were also measured by the ELISA method. TGF-beta serum levels were significantly lower in patients evaluated outside the pollen season in comparison with the other 2 situations. SLIT induced the significantly highest TGF-beta serum levels. There was a significant negative relationship between TGF-beta and eosinophils in patients after SLIT. IgG ...Continue Reading

Citations

Nov 30, 2011·International Archives of Allergy and Immunology·Ayhan SogutHasan Yuksel
Aug 13, 2010·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Giorgio Ciprandi, Maria Angela Tosca
Mar 15, 2011·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G Ciprandi, M A Tosca
Jun 15, 2011·Current Opinion in Allergy and Clinical Immunology·Gianenrico SennaGiovanni Passalacqua
Jan 15, 2011·Current Opinion in Otolaryngology & Head and Neck Surgery

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