Serum Triamcinolone Levels following Cervical Interlaminar Epidural Injection

Pain Research & Management : the Journal of the Canadian Pain Society = Journal De La Société Canadienne Pour Le Traitement De La Douleur
Tim J LamerW Michael Hooten

Abstract

Cervical interlaminar epidural steroid injections (ESIs) are commonly performed procedures to treat painful cervical radiculopathy, but little is known about the systemic absorption and serum levels of steroids following injection. The primary objective of this study was to investigate the pharmacokinetics of fluoroscopy-guided cervical epidural-administered triamcinolone acetonide in a cohort of patients with cervical radicular pain seeking treatment in a pain medicine clinic. The study cohort included eight patients undergoing a fluoroscopically guided C7-T1 interlaminar ESI at a pain medicine specialty clinic. Blood was collected prior to the ESI and on days 1, 2, 4, 6, 8, 14, 21, 28, 35, and 42 following the injection. The sample extract was analyzed by tandem mass spectrometry. The terminal elimination half-life of cervical epidural-administered triamcinolone in a noncompartmental analysis was 219 hours. In the noncompartmental analysis, peak triamcinolone concentrations of 5.4 ng/mL were detected within 22.1 hours after administration. The pharmacokinetics of cervical epidural-administered triamcinolone is consistent with our previous study of lumbar ESI, demonstrating that the elimination half-life is longer than that wh...Continue Reading

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Dec 10, 2015·Regional Anesthesia and Pain Medicine·W Michael HootenTim J Lamer

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Citations

Mar 30, 2019·PM & R : the Journal of Injury, Function, and Rehabilitation·Alison StoutChristopher J Standaert
Nov 2, 2019·The Journal of Obstetrics and Gynaecology Research·Kittipat Charoenkwan, Chalaithorn Nantasupha
Dec 14, 2019·Skeletal Radiology·Jonathon FloranceMiriam A Bredella
Jun 20, 2020·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Steven P CohenChristopher R Phillips
Jan 18, 2019·Pain Research & Management : the Journal of the Canadian Pain Society = Journal De La Société Canadienne Pour Le Traitement De La Douleur·Junnan WangZhijian Fu
Sep 9, 2020·Pain Practice : the Official Journal of World Institute of Pain·Jerry KalangaraMerin Kuruvilla
Jan 21, 2021·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Kevin C J YuenJames W Findling
Nov 1, 2020·British Medical Bulletin·Filippo MiglioriniAlice Baroncini
Feb 4, 2021·Anesthesia and Pain Medicine·Min Soo Lee, Ho Sik Moon
Nov 3, 2021·Journal of Forensic Sciences·Lorenzo GittoCarolyn Revercomb

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