Serum triglycerides and risk for death in Stage 3 and Stage 4 chronic kidney disease.

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Sankar D NavaneethanJoseph V Nally

Abstract

An elevated triglyceride level is associated with cardiovascular and all-cause mortality in the general population. The associations between serum triglyceride and all-cause mortality among patients with chronic kidney disease (CKD) are unclear. Patients with Stage 3 and Stage 4 CKD (estimated glomerular filtration rate 15-59 mL/min/1.73 m(2)) who had serum triglycerides measured prior to being classified as CKD were included. We examined the associations of serum triglyceride levels with all-cause mortality among 25 641 Stage 3 and Stage 4 CKD patients using Cox proportional hazard models and Kaplan-Meier survival curves. In the Cox model, after adjusting for relevant covariates including other lipid parameters, serum triglyceride level 150-199 mg/dL was not associated with death [hazard ratio (HR) 1.00, 95% confidence interval (95% CI) 0.92-1.10] relative to serum triglyceride <150 mg/dL while serum triglyceride ≥ 200 mg/dL was associated with a 11% increased hazard for death (95% CI 1.01-1.22). Age modified the association between serum triglyceride levels ≥ 200 mg/dL and mortality with patients <65 years having a 38% higher hazard for death (95% CI 1.15-1.65) and ≥ 65 years with no increased risk for death (HR 0.97, 95% CI ...Continue Reading

References

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Citations

Jan 17, 2013·Clinical Nephrology·Sankar D NavaneethanJoseph V Nally
Feb 16, 2013·Clinical Journal of the American Society of Nephrology : CJASN·Sankar D NavaneethanJoseph V Nally
Aug 1, 2020·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Daniel BunoutEduardo Lorca
Sep 29, 2019·Journal of Clinical Lipidology·Melissa SoohooElani Streja

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