Abstract
Low-density lipoprotein cholesterol predicts cardiovascular events in patients with diabetes. However, it is uncertain whether serum triglycerides level is also associated with an occurrence of future cardiovascular events in diabetic patients. We aimed to test whether serum triglycerides is associated with first cardiovascular events in diabetic patients. We recruited 5042 participants with diabetes mellitus from the standard versus intEnsive statin therapy for hypercholesteroleMic Patients with diAbetic retinopaTHY (EMPATHY), multicenter, prospective, randomized, open-label, blinded-endpoint study. Median follow-up was three years. We evaluated an association of serum triglycerides with first cardiovascular events in cox-regression hazard models adjusted by age, sex, hypertension, current smoking, low-density lipoprotein cholesterol, and body mass index. Cardiovascular events were defined as (a) major adverse cardiac events including myocardial infarction, stroke, or cardiac death; and (b) cardiovascular diseases including myocardial infarction, unstable angina, ischemic stroke, or large artery disease or peripheral arterial disease. Serum triglycerides were associated with major adverse cardiac events (adjusted hazard ratio:...Continue Reading
References
Nov 1, 1985·American Heart Journal·W B Kannel
Aug 18, 2000·The American Journal of Cardiology·M A AustinD S Sharp
Sep 6, 2001·Circulation·A R SharrettUNKNOWN Atherosclerosis Risk in Communities Study Group
Jun 20, 2003·Lancet·Rory CollinsUNKNOWN Heart Protection Study Collaborative Group
Aug 25, 2004·Lancet·Helen M ColhounUNKNOWN CARDS investigators
Apr 3, 2007·Lancet·Mitsuhiro YokoyamaUNKNOWN Japan EPA lipid intervention study (JELIS) Investigators
Jul 20, 2007·JAMA : the Journal of the American Medical Association·Børge G NordestgaardAnne Tybjaerg-Hansen
Feb 19, 2008·Journal of the American College of Cardiology·Michael MillerUNKNOWN PROVE IT-TIMI 22 Investigators
Aug 8, 2009·The American Journal of Cardiology·Ole FaergemanUNKNOWN Steering Committees of IDEAL and TNT Trials
Dec 8, 2009·Atherosclerosis·Audrey BonaventureChristophe Tzourio
Apr 29, 2011·Diabetes Care·Caroline K KramerMirela J Azevedo
Sep 17, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Renske G WieberdinkM Arfan Ikram
Aug 13, 2013·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Z Reiner
Oct 8, 2013·Nature Genetics·Ron DoSekar Kathiresan
Dec 18, 2013·Journal of Atherosclerosis and Thrombosis·Tamio TeramotoUNKNOWN Japan Atherosclerosis Society Committee for Epidemiology and Clinical Management of Atherosclerosis
Dec 20, 2013·Circulation·Frank M SacksVincent J Carey
May 30, 2015·Journal of the American College of Cardiology·Gregory G SchwartzAnders G Olsson
Jan 2, 2016·Atherosclerosis·Christina Reith, Jane Armitage
Mar 11, 2016·Journal of Atherosclerosis and Thrombosis·Kenji UeshimaUNKNOWN EMPATHY study group
Apr 29, 2016·European Heart Journal·Børge G NordestgaardUNKNOWN European Atherosclerosis Society (EAS) and the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) join
Aug 28, 2016·European Heart Journal·Alberico L CatapanoUNKNOWN ESC Scientific Document Group
Aug 30, 2016·Journal of Atherosclerosis and Thrombosis·Hayato TadaKenshi Hayashi
Dec 29, 2016·JAMA Cardiology·Marshall B ElamUNKNOWN ACCORDION Study Investigators
Mar 17, 2017·Nature Reviews. Cardiology·Željko Reiner
May 5, 2017·JAMA Ophthalmology·Jing XieTien Yin Wong
May 24, 2017·European Heart Journal Supplements : Journal of the European Society of Cardiology·Roberto FerrariAlberico L Catapano
Jun 7, 2017·Stroke; a Journal of Cerebral Circulation·Yasuhiko KubotaUNKNOWN JPHC Study Group
Oct 31, 2017·Nature Genetics·Dajiang J LiuSekar Kathiresan
Oct 24, 2018·Diabetes Care·Hiroshi ItohIssei Komuro
Citations
Sep 19, 2018·Diabetes, Obesity & Metabolism·Gregory A NicholsSergio Fazio
Apr 12, 2019·European Journal of Preventive Cardiology·Nathalia Gonzalez-JaramilloArjola Bano
Jun 13, 2019·European Journal of Preventive Cardiology·Massimo F Piepoli
Feb 6, 2020·Circulation Journal : Official Journal of the Japanese Circulation Society·Hayato TadaMasa-Aki Kawashiri
Apr 29, 2020·European Journal of Preventive Cardiology·Yoshihiro SaitoIssei Komuro
May 8, 2019·Journal of Atherosclerosis and Thrombosis·Hayato TadaMasa-Aki Kawashiri
Apr 17, 2019·Cardiovascular Diabetology·Xiaofeng YeLu-Lu Chen
Nov 21, 2018·Nutrients·Hayato TadaMasa-Aki Kawashiri
Oct 3, 2019·Diabetes Care·Wenjun FanNathan D Wong
Feb 9, 2021·Journal of Atherosclerosis and Thrombosis·Hayato Tada
Feb 22, 2021·European Journal of Preventive Cardiology·Yoshihiro SaitoIssei Komuro
Feb 19, 2021·Circulation Journal : Official Journal of the Japanese Circulation Society·Masakazu YamagishiUNKNOWN Japanese Circulation Society Working Group
Jun 18, 2021·Frontiers in Cardiovascular Medicine·Shuang WangPing Yang
Aug 8, 2021·International Journal of Environmental Research and Public Health·Chin-Yuan HsuMin-Yen Hsu