Serum triglycerides predict first cardiovascular events in diabetic patients with hypercholesterolemia and retinopathy

European Journal of Preventive Cardiology
Hayato TadaMasakazu Yamagishi

Abstract

Low-density lipoprotein cholesterol predicts cardiovascular events in patients with diabetes. However, it is uncertain whether serum triglycerides level is also associated with an occurrence of future cardiovascular events in diabetic patients. We aimed to test whether serum triglycerides is associated with first cardiovascular events in diabetic patients. We recruited 5042 participants with diabetes mellitus from the standard versus intEnsive statin therapy for hypercholesteroleMic Patients with diAbetic retinopaTHY (EMPATHY), multicenter, prospective, randomized, open-label, blinded-endpoint study. Median follow-up was three years. We evaluated an association of serum triglycerides with first cardiovascular events in cox-regression hazard models adjusted by age, sex, hypertension, current smoking, low-density lipoprotein cholesterol, and body mass index. Cardiovascular events were defined as (a) major adverse cardiac events including myocardial infarction, stroke, or cardiac death; and (b) cardiovascular diseases including myocardial infarction, unstable angina, ischemic stroke, or large artery disease or peripheral arterial disease. Serum triglycerides were associated with major adverse cardiac events (adjusted hazard ratio:...Continue Reading

References

Apr 3, 2007·Lancet·Mitsuhiro YokoyamaUNKNOWN Japan EPA lipid intervention study (JELIS) Investigators
Jul 20, 2007·JAMA : the Journal of the American Medical Association·Børge G NordestgaardAnne Tybjaerg-Hansen
Feb 19, 2008·Journal of the American College of Cardiology·Michael MillerUNKNOWN PROVE IT-TIMI 22 Investigators
Dec 8, 2009·Atherosclerosis·Audrey BonaventureChristophe Tzourio
Sep 17, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Renske G WieberdinkM Arfan Ikram
Dec 18, 2013·Journal of Atherosclerosis and Thrombosis·Tamio TeramotoUNKNOWN Japan Atherosclerosis Society Committee for Epidemiology and Clinical Management of Atherosclerosis
May 30, 2015·Journal of the American College of Cardiology·Gregory G SchwartzAnders G Olsson
Jan 2, 2016·Atherosclerosis·Christina Reith, Jane Armitage
Aug 28, 2016·European Heart Journal·Alberico L CatapanoUNKNOWN ESC Scientific Document Group
Dec 29, 2016·JAMA Cardiology·Marshall B ElamUNKNOWN ACCORDION Study Investigators
Mar 17, 2017·Nature Reviews. Cardiology·Željko Reiner
May 24, 2017·European Heart Journal Supplements : Journal of the European Society of Cardiology·Roberto FerrariAlberico L Catapano
Jun 7, 2017·Stroke; a Journal of Cerebral Circulation·Yasuhiko KubotaUNKNOWN JPHC Study Group
Oct 31, 2017·Nature Genetics·Dajiang J LiuSekar Kathiresan

❮ Previous
Next ❯

Citations

Apr 12, 2019·European Journal of Preventive Cardiology·Nathalia Gonzalez-JaramilloArjola Bano
Jun 13, 2019·European Journal of Preventive Cardiology·Massimo F Piepoli
Feb 6, 2020·Circulation Journal : Official Journal of the Japanese Circulation Society·Hayato TadaMasa-Aki Kawashiri
Apr 29, 2020·European Journal of Preventive Cardiology·Yoshihiro SaitoIssei Komuro
May 8, 2019·Journal of Atherosclerosis and Thrombosis·Hayato TadaMasa-Aki Kawashiri
Feb 22, 2021·European Journal of Preventive Cardiology·Yoshihiro SaitoIssei Komuro
Feb 19, 2021·Circulation Journal : Official Journal of the Japanese Circulation Society·Masakazu YamagishiUNKNOWN Japanese Circulation Society Working Group
Aug 8, 2021·International Journal of Environmental Research and Public Health·Chin-Yuan HsuMin-Yen Hsu

❮ Previous
Next ❯

Software Mentioned

R

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Cardiovascular Disorder in Diabetes

Diabetes is associated with an increased risk of cardiovascular disorders and heart failure. Discover the latest research here.