Serum troponin T concentration as a predictor of mortality in hemodialysis and peritoneal dialysis patients

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
Bas HavekesNECOSAD Study Group

Abstract

Troponin T is a good predictor of all-cause and cardiovascular mortality in cardiac patients. Although it is known that troponin T is an independent risk factor in dialysis patients as well, its prognostic value when measured routinely in clinical practice, particularly in addition to other risk indicators, is unclear. A cohort of 847 patients who started dialysis therapy between 1997 and 2001 and participated in a multicenter follow-up study was examined. Clinical data were determined 3 months after the start of dialysis therapy. Patients were followed up until date of death or censoring in November 2003. For patients with troponin T values of 0.05 to 0.10 microg/L, hazard ratio for all-cause mortality was 2.2 (95% confidence interval [CI], 1.7 to 2.8) compared with patients with values less than 0.05 microg/L. For patients with values greater than 0.10 microg/L (11%), hazard ratio was 3.3 (95% CI, 2.5 to 4.5). A survival model with clinical and laboratory risk indicators yielded an area under the curve of 0.81, which did not increase when troponin T level was added to the model. The area under the curve for troponin T level alone was 0.67. No important differences were found between patients on hemodialysis or peritoneal dial...Continue Reading

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Citations

Jan 16, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ea Wha KangSeung Hyeok Han
May 15, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Andrzej JaroszyńskiAndrzej Książek
Jan 1, 2009·F1000 Medicine Reports·Angela Yee-Moon Wang
Oct 30, 2012·Indian Heart Journal·Amir Farhang Zand ParsaMitra Mahdavimazdeh
Nov 27, 2007·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Sangeetha SatyanRajiv Agarwal
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Jan 18, 2008·Journal of Clinical Laboratory Analysis·Martina MontagnanaGian Cesare Guidi
Sep 30, 2014·European Journal of Clinical Investigation·Chen ZhaoFengxian Huang
Feb 5, 2014·Nature Reviews. Nephrology·Dinanda J de JagerFriedo W Dekker
Mar 7, 2008·Journal of the American Society of Nephrology : JASN·Angela Yee-Moon Wang, Kar-Neng Lai
Feb 26, 2015·Journal of the American Society of Nephrology : JASN·Michael WalshPhillip J Devereaux
Mar 23, 2019·Kidney Research and Clinical Practice·Changhyun LeeSeung Hyeok Han
Dec 14, 2019·The American Journal of Emergency Medicine·Brit LongJonathan M Bronner
Aug 26, 2021·World Journal of Nephrology·Panupong HansrivijitWisit Cheungpasitporn

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