Serum tumor markers after renal transplantation

Transplantation
R OberbauerG Mayer

Abstract

The overall incidence of malignancy in renal transplant recipients is 100-fold higher compared with age matched controls. Routine clinical evaluation therefore often includes the determination of serum tumor markers AFP, CA19-9, CEA, CA125, CA15-3, PSA, and calcitonin. We evaluated the specificity and the sensitivity of these markers in 575 renal allograft recipients. Specificity varied between 0.69 (CA 125) and 0.96 (PSA) in 532 patients without cancer. Cyclosporine therapy and excretory allograft function did not affect marker concentration; impaired liver function was associated with significantly elevated AFP, CA19-9, CA125, and CA15-3 levels. In 43 patients with malignancies the sensitivity of the markers ranged between 0.2 (CEA) and 1 (CA 125, CA 15-3). We therefore conclude that routine screening of the transplant population with serum tumor markers is not useful because of the low sensitivity and specificity of these tests.

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Citations

Nov 24, 1999·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·H NägeleW Rödiger
Mar 22, 2000·Current Opinion in Urology·A Schmidt, R Oberbauer
Jan 5, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Martin ZeierEberhard Ritz
Oct 16, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·K ChamieR W deVere White
Jan 15, 2013·Clinical Chemistry and Laboratory Medicine : CCLM·Kenan TurgutalpAhmet Kıykım
Mar 21, 2001·Renal Failure·S H SobkiA A Khader

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