PMID: 8443749Mar 15, 1993Paper

Serum tumor markers CEA, CA 50, TATI, and NSE in lung cancer screening

Cancer
J JärvisaloA Aromaa

Abstract

There are no effective means for screening for lung cancer, so the authors assessed the utility of four lung cancer tumor makers for screening. A case-control study, nested in a cohort study based on the linkage of records of health survey examinees with Finnish Cancer Registry records, was used to test the validity of tumor markers carcinoembryonic antigen (CEA), tumor-associated trypsin inhibitor (TATI), neuron-specific enolase (NSE), and CA 50 in lung cancer screening. Ten years after health examinations, record linkage indicated that 187 men had lung cancer; 344 control subjects, matched for age, sex, and municipality were drawn from the same records. The data allowed assessment of the sensitivity of the marker assays at a 95% specificity level, which was highest for CEA (17% at a concentration level of 5.3 micrograms/l). Logistic discrimination analysis indicated that of the other markers, only TATI, when used in combination, improved the discriminatory power of CEA. CEA and TATI levels correlated significantly with smoking. They also showed a significant gradient toward increasing risk of lung cancer from the lowest to the highest quintiles of marker levels (for CEA, crude relative risk between the highest and lowest quin...Continue Reading

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Citations

Sep 1, 1996·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·F CasamassimaM Ruggiero
Dec 23, 2003·Immunology Letters·Marek JakóbisiakJakub Gołab
Feb 13, 2001·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·F AlataşS Demir
Jun 5, 2008·Environmental Health : a Global Access Science Source·Sam De CosterNik van Larebeke
Nov 24, 1999·Biochemical and Biophysical Research Communications·K Wakiya, M Shibuya
Jan 19, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Barbara KozakiewiczMałgorzata Stefaniak
Aug 1, 1994·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·A J Vangsted
Jan 1, 1994·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J A Ledermann
Sep 10, 2015·Tumori·Barbara KozakiewiczMałgorzata Stefaniak
Mar 7, 2006·Critical Reviews in Clinical Laboratory Sciences·Annukka Paju, Ulf-Håkan Stenman
Dec 15, 2015·Clinical Chemistry·Kati RäsänenUlf-Håkan Stenman
May 14, 2020·International Journal of Molecular Sciences·Milena Matuszczak, Maciej Salagierski

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