Serum tumor necrosis factor associated with malaria in patients in the Solomon Islands

Transactions of the Royal Society of Tropical Medicine and Hygiene
G A ButcherI A Clark

Abstract

There is now significant evidence that tumor necrosis factor (TNF) is involved in the pathogenesis of malaria. We have tested sera from patients presenting with a febrile illness admitted to hospital in Honiara, Solomon Islands, for the presence of TNF, interferon-gamma, and interleukin-1 (IL-1). This study differs from previous reports as the subjects were mainly adults from a semi-immune population living in an endemic area. The results from 2 different commercially-available assays for TNF were compared, and one was found to be superior to the other. Serum TNF concentrations correlated with malarial parasite density and the patients' temperatures, but not with interferon or IL-1. The results are discussed in the context of the immunopathology of this disease.

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Citations

Jan 1, 1993·Stem Cells·S de Kossodo, G E Grau
Jan 1, 1994·Biotherapy·W M Eling, P G Kremsner
Nov 19, 2002·International Journal for Parasitology·Andreas Heddini
Dec 12, 1997·International Journal for Parasitology·I A ClarkL S Jacobson
Aug 25, 2005·Transactions of the Royal Society of Tropical Medicine and Hygiene·Joon-Sup YeomJae-Won Park
May 1, 1996·Transactions of the Royal Society of Tropical Medicine and Hygiene·F M Al YamanI A Clark
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Jul 31, 2003·Pharmacology & Therapeutics·Ian A Clark, William B Cowden
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Apr 10, 2010·Glycobiology·Françoise Debierre-Grockiego, Ralph T Schwarz
May 1, 1994·Parasite Immunology·K A RockettI A Clark
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May 11, 2002·Critical Care Medicine·Ian Clark, Melissa Awburn
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