Serum unconjugated estriol in the menstrual cycle and early pregnancy

Gynecologic Investigation
U RajuM Levitz

Abstract

A radioimmunoassay for serum unconjugated estriol in the menstrual cycle with a sensitivity of about 5 pg/ml is described. 8 cycles were studied. In 2 cycles, single spikes of 22 and 30 pg/ml were obtained. In 3 cycles, concentrations of 4-5 pg/ml were found whereas in the other 3 studies, no estriol was detected. In general, peaks of estriol corresponded to peaks in estradiol plus estrone. Patients in 4-12 weeks of gestation were also studied. Concentrations as high as 262 pg/ml were found but in isolated instances, no estriol was detected. The results support the view that in contrast to the pregnant state, in the normal menstrual cycle, the bulk of the estriol produced is conjugated before release into the blood.

Citations

Apr 1, 1984·Journal of Steroid Biochemistry·C Longcope
Apr 1, 1984·Journal of Steroid Biochemistry·H Adlercreutz, J Vähäpassi
Apr 1, 1984·Journal of Steroid Biochemistry·U RajuM Levitz
Jan 1, 1983·Pharmacology & Therapeutics·J H Clark, B M Markaverich
Jun 1, 1991·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·G Esposito

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