Serum uric acid and AKI: is it time?

Clinical Kidney Journal
Manish Kaushik, Jason Chon Jun Choo

Abstract

Acute kidney injury (AKI) is a well-recognized complication in hospitalized patients, with associated mortality and morbidity. Studies that aim to prevent or reverse AKI using pharmacological and interventional therapies in clinical practice have been disappointing. Work is continuing to identify potentially modifiable risk factors for AKI. Early identification and modification of these risk factors may help prevent or favorably influence the outcome of AKI. The role of uric acid as a potential risk factor is being revisited in chronic kidney disease and AKI. Apart from the established crystal precipitation with profound hyperuricemia, various non-crystal mechanisms have also been proposed in the pathogenesis of AKI. The association of serum uric acid levels with the development of AKI has been reported in various clinical settings. Together, the results of these studies highlight hyperuricemia as a potential risk factor of AKI and the need for further work on this subject.

References

Apr 30, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Kevin NashSusan Hou
Nov 26, 2004·Journal of the American Society of Nephrology : JASN·Charuhas V ThakarEmil P Paganini
Dec 22, 2004·Kidney International·Laura G Sánchez-LozadaJaime Herrera-Acosta
Sep 24, 2005·Journal of the American Society of Nephrology : JASN·Glenn M ChertowDavid W Bates
Dec 27, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Yui-Pong SiuTze-Hoi Kwan
Nov 2, 2006·Current Opinion in Critical Care·Shigehiko Uchino
Apr 28, 2007·Contributions to Nephrology·Eric A J Hoste, John A Kellum
Aug 21, 2007·Clinical Journal of the American Society of Nephrology : CJASN·A Ahsan EjazRichard J Johnson
Aug 21, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Sang Kyung JoMark D Okusa
Mar 21, 2008·Clinical Journal of the American Society of Nephrology : CJASN·Jonathan HimmelfarbJohn A Kellum
Aug 18, 2010·Blood Purification·Yi FangPan Lin
Oct 18, 2011·Seminars in Nephrology·Michiko ShimadaA Ahsan Ejaz
Feb 22, 2012·The American Journal of Medicine·Vijay LapsiaA Ahsan Ejaz
Mar 28, 2012·Current Opinion in Nephrology and Hypertension·Edward D Siew, Serpil M Deger
Apr 17, 2012·Medical Hypotheses·A Ahsan EjazRichard J Johnson
Jun 1, 2012·International Urology and Nephrology·A Ahsan EjazRichard J Johnson
Oct 13, 2012·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Diana I JalalGiovanni Targher
Apr 2, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Richard J JohnsonEberhard Ritz
Sep 24, 2014·Journal of Cardiothoracic and Vascular Anesthesia·Kyoung-Woon JoungIn-Cheol Choi
Jan 18, 2015·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Marian GoicoecheaJose Luño
Aug 8, 2015·Clinical Kidney Journal·Wisit CheungpasitpornNelson Leung
Nov 28, 2015·Clinical Kidney Journal·Gareth RobertsAled Phillips
Jan 23, 2016·Clinical Kidney Journal·Wisit CheungpasitpornStephen B Erickson

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Citations

Jul 22, 2021·Jornal brasileiro de nefrologia : ʹorgão oficial de Sociedades Brasileira e Latino-Americana de Nefrologia·Sandra Rodríguez-SalgueiroVivian Molina-Cuevas

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