Serum Uric Acid and Mortality Form Cardiovascular Disease: EPOCH-JAPAN Study.

Journal of Atherosclerosis and Thrombosis
Wen ZhangEPOCH-JAPAN GROUP

Abstract

To investigate the relationship between serum uric acid levels and cardiovascular disease in Asians. We examined the above relationship using the data of Evidence for Cardiovascular Prevention from Observational Cohorts in Japan (EPOCH-JAPAN Study). The data of 36,313 subjects (15,628 men and 20,685 women aged 35-89 years without histories of stroke, coronary heart disease, or cancer at baseline) were used for the analyses. Sex-specific hazard ratios (HRs) of mortality from cardiovascular disease were estimated according to the quintiles of serum uric acid using Cox hazard models stratified by cohorts. During 441,771 person-years of follow-up, we documented 1,288 cardiovascular deaths. A J- or U-shaped relationship between serum uric acid level and cardiovascular disease mortality was observed. Compared with the lowest quintile of serum uric acid levels, the highest quintile was associated with an increased cardiovascular disease mortality in men [HR: 1.28; 95% confidence interval (CI): 1.01-1.63] and women (HR: 1.51; 95% CI: 1.14-1.99). However, there was no significant association with mortality from stroke, coronary heart disease or heart failure in both men and women. This large pooled analysis in Japan suggested a J- or U-...Continue Reading

References

Jan 1, 1992·Journal of Molecular Evolution·X W WuC T Caskey
Feb 6, 1991·JAMA : the Journal of the American Medical Association·E L Barrett-ConnorS L Edelstein
Jan 1, 1988·Journal of Clinical Epidemiology·R D AbbottW P Castelli
Jul 21, 1993·JAMA : the Journal of the American Medical Association·F P CappuccioM Trevisan
Apr 1, 1998·Archives of Internal Medicine·J R Sowers
Jul 3, 1999·Annals of Internal Medicine·B F CulletonD Levy
Apr 19, 2002·Molecular Biology and Evolution·Masako OdaNaoyuki Takahata
Sep 15, 2005·Internal Medicine·Ryuichi KawamotoAtsushi Kamitani
Apr 13, 2007·American Journal of Physiology. Cell Physiology·Yuri Y SautinRichard J Johnson
Aug 19, 2007·Circulation·Hyon K Choi, Gary Curhan
Nov 27, 2007·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Takeshi BabaMasazumi Akahoshi
Apr 30, 2008·Hypertension·Yoshitaka MurakamiUNKNOWN Evidence for Cardiovascular Prevention From Observational Cohorts in Japan Research Group (EPOCH-JAPAN)
Aug 30, 2008·JAMA : the Journal of the American Medical Association·Daniel I FeigRichard J Johnson
Oct 24, 2008·The New England Journal of Medicine·Daniel I FeigRichard J Johnson
Jul 1, 2009·Arthritis and Rheumatism·Seo Young KimDaniel A Albert
Nov 19, 2009·Circulation. Heart Failure·Eswar Krishnan
Mar 2, 2010·Arthritis Care & Research·Seo Young KimDaniel A Albert
Nov 30, 2010·Preventive Medicine·Yoshitaka MurakamiUNKNOWN EPOCH-JAPAN Research Group
Dec 18, 2010·Stroke; a Journal of Cerebral Circulation·Sergio AmaroAngel Chamorro
Jun 29, 2012·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Akira FujiyoshiUNKNOWN Observational Cohorts in Japan (EPOCH-JAPAN) Research Group
Jan 15, 2013·Journal of the American Heart Association·Sin-ya NagasawaUNKNOWN Evidence for Cardiovascular Prevention from Observational Cohorts in Japan (EPOCH-JAPAN) Research Group
Mar 19, 2014·Hypertension·Kei AsayamaUNKNOWN Evidence for Cardiovascular Prevention From Observational Cohorts in Japan (EPOCH-JAPAN) Research Group
Jan 21, 2015·Hypertension·Michihiro SatohUNKNOWN Evidence for Cardiovascular Prevention From Observational Cohorts in Japan (EPOCH–JAPAN) Research Group*
Mar 6, 2015·Journal of Atherosclerosis and Thrombosis·Ying ChenGuang Ning

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Citations

May 14, 2016·Journal of Atherosclerosis and Thrombosis·Hirohito Metoki
Feb 17, 2017·Journal of Atherosclerosis and Thrombosis·Yoko SotodaIchiro Wakabayashi
Sep 7, 2017·Journal of Hypertension·Kei AsayamaUNKNOWN Evidence for Cardiovascular Prevention From Observational Cohorts in Japan (EPOCH-JAPAN) Research Group
Nov 16, 2017·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ching-Wei TsaiChin-Chi Kuo
Apr 26, 2018·Arthritis & Rheumatology·Sung Kweon ChoSeungho Ryu
Aug 24, 2018·Journal of Atherosclerosis and Thrombosis·Makoto KinoshitaUNKNOWN Committee for Epidemiology and Clinical Management of Atherosclerosis
Mar 31, 2017·Journal of the American Heart Association·Chongke ZhongYonghong Zhang
Jul 19, 2017·International Heart Journal·Kensuke NomaYukihito Higashi
Mar 12, 2020·Metabolic Syndrome and Related Disorders·Marek VeckaMiroslav Zeman
Jan 19, 2020·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Satoko SakataToshiharu Ninomiya
Jan 29, 2020·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Ryusuke AeMasanari Kuwabara
Jan 29, 2020·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Jiaqi LiUNKNOWN CIRCS investigators
Feb 23, 2019·European Journal of Clinical Nutrition·W TuN Wang
Dec 11, 2019·Journal of Clinical Medicine·Po-Hsun ChenChia-Lin Lee
Aug 4, 2019·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Satoshi UmemuraNobuhito Hirawa
Nov 27, 2019·International Journal of Environmental Research and Public Health·Seung Yun LeeKyong-Hee Jung
Jan 17, 2020·Metabolites·Camila WeschenfelderAline Marcadenti
Aug 15, 2020·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Kazuma MoriTetsuji Miura
Jul 2, 2020·Journal of Clinical Medicine·Stefano Masi Micro-And Macro-Circulation Of The Italian Society Of Hypertension Siia
Jan 17, 2020·Journal of Cardiothoracic Surgery·Yiran ZhangLiang Ma
Sep 8, 2020·American Journal of Physiology. Endocrinology and Metabolism·Masato Furuhashi
Oct 24, 2020·European Journal of Internal Medicine·Leonard D BrowneAustin G Stack
Nov 28, 2020·Frontiers in Cardiovascular Medicine·Ziliang SongXu Liu
Apr 14, 2021·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Lijun LiHao Xue
Feb 19, 2021·Circulation Journal : Official Journal of the Japanese Circulation Society·Masakazu YamagishiUNKNOWN Japanese Circulation Society Working Group
May 25, 2021·Journal of Clinical Biochemistry and Nutrition·Yunan DongLi Tian
Jun 13, 2021·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Masato FuruhashiTetsuji Miura
Oct 8, 2020·Arthritis Care & Research·Kristin M D'SilvaHyon K Choi
Jul 29, 2021·Chinese Medical Journal·Dong-Yuan ChangMing-Hui Zhao
May 11, 2020·Journal of the Neurological Sciences·Aniqa B AlamAlvaro Alonso

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