Serum Uric Acid and Risk of CKD in Type 2 Diabetes.

Clinical Journal of the American Society of Nephrology : CJASN
Salvatore De CosmoAMD-Annals Study Group

Abstract

Serum uric acid may predict the onset and progression of kidney disease, but it is unclear whether uric acid is an independent risk factor for diabetic nephropathy. Our aim was to study the relationship between uric acid levels and the development of CKD components in patients with type 2 diabetes. Longitudinal study of a cohort of patients with type 2 diabetes from the database of the Italian Association of Clinical Diabetologists network. From a total of 62,830 patients attending the diabetes centers between January 1, 2004, and June 30, 2008, we considered those with baseline eGFR values ≥60 ml/min per 1.73 m2 and normal albumin excretion (n=20,142). Urinary albumin excretion, GFR, and serum uric acid were available in 13,964 patients. We assessed the association of serum uric acid quintiles with onset of CKD components by multinomial logistic regression model adjusting for potential confounders. We calculated the relative risk ratios (RRRs) for eGFR <60 ml/min per 1.73 m2, albuminuria, and their combination at 4 years. At 4-year follow-up, 1109 (7.9%) patients developed GFR <60 ml/min per 1.73 m2 with normoalbuminuria, 1968 (14.1%) had albuminuria with eGFR ≥60 ml/min per 1.73 m2, and 286 (2.0%) had albuminuria with eGFR <6...Continue Reading

References

Dec 23, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·J SyrjänenA Pasternack
Apr 12, 2001·European Journal of Clinical Investigation·S BoG Pagano
Nov 22, 2002·Journal of the American Society of Nephrology : JASN·Duk-Hee KangRichard J Johnson
Dec 22, 2004·Kidney International·Laura G Sánchez-LozadaJaime Herrera-Acosta
Dec 27, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Yui-Pong SiuTze-Hoi Kwan
Jun 2, 2006·Journal of the American Society of Nephrology : JASN·Marcello TonelliAmit X Garg
Dec 1, 2007·American Journal of Hypertension·Francesca ViazziRoberto Pontremoli
Mar 14, 2008·Journal of the American Society of Nephrology : JASN·Daniel E WeinerAndrew S Levey
May 13, 2008·Acta Cardiologica·Massimiliano PinelliMaido Castiglioni
Oct 24, 2008·The New England Journal of Medicine·Daniel I FeigRichard J Johnson
May 6, 2009·Annals of Internal Medicine·Andrew S LeveyUNKNOWN CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)
May 16, 2009·Journal of the American Society of Nephrology : JASN·Toshiharu NinomiyaUNKNOWN ADVANCE Collaborative Group
May 22, 2009·American Journal of Physiology. Renal Physiology·Tomoki KosugiTakahiko Nakagawa
Dec 8, 2009·Diabetes Research and Clinical Practice·Nigel UnwinDavid Whiting
Jun 12, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Marian GoicoecheaJosé Luño
Aug 21, 2010·Diabetic Medicine : a Journal of the British Diabetic Association·A NicolucciUNKNOWN AMD-Annals Study Group
Jul 9, 2011·Journal of Hypertension·Giuseppe PennoUNKNOWN Renal Insufficiency And Cardiovascular Events (RIACE) Study Group
Aug 5, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A HaririanM R Weir
Nov 28, 2012·Clinical and Experimental Nephrology·Kazuko SuzukiIsao Kubota
Jan 4, 2013·American Journal of Physiology. Renal Physiology·Eun-Sun RyuDuk-Hee Kang
Jan 8, 2013·The Medical Clinics of North America·Marcus G Pezzolesi, Andrzej S Krolewski
Apr 2, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Richard J JohnsonEberhard Ritz
Sep 26, 2013·Diabetes·Richard J JohnsonMiguel A Lanaspa
Oct 12, 2013·European Journal of Clinical Investigation·Chang-Mo OhJae-Hong Ryoo
Jan 9, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Salvatore De CosmoUNKNOWN AMD-Annals Study Group
Jun 4, 2014·The Journal of Clinical Investigation·Kimberly ReidyKatalin Susztak
Jan 18, 2015·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Marian GoicoecheaJose Luño

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Citations

Jun 22, 2016·Journal of Diabetes and Its Complications·Vendula BartákováKateřina Kaňková
Feb 9, 2017·Canadian Journal of Physiology and Pharmacology·Ravi NistalaLakshmi Pulakat
Jul 28, 2016·Journal of Hypertension·Salvatore De CosmoUNKNOWN AMD-Annals Study Group
Apr 20, 2017·PloS One·Francesca ViazziUNKNOWN AMD-Annals Study Group
Dec 10, 2016·Diabetes/metabolism Research and Reviews·Antonio PacilliUNKNOWN AMD-Annals Study Group
Nov 30, 2016·Hemodialysis International·Tushar Chopra, Mitchell H Rosner
Mar 3, 2018·Current Diabetes Reports·Ambreen Gul, Philip Zager
Apr 19, 2018·Diabetes/metabolism Research and Reviews·Giuseppina T RussoUNKNOWN BetaDecline Study Group
Apr 21, 2018·Journal of Hypertension·Francesca ViazziUNKNOWN AMD-Annals Study Group
Aug 25, 2018·PloS One·Fernando E García-ArroyoL Gabriela Sánchez-Lozada
Sep 25, 2017·Journal of the American Heart Association·Francesca ViazziUNKNOWN AMD‐Annals Study Group
Feb 6, 2018·BMC Geriatrics·Giuseppina T RussoUNKNOWN AMD-Annals Study Group
Jan 10, 2019·Journal of Hypertension·Francesca ViazziUNKNOWN AMD-Annals Study Group
Feb 15, 2019·Diabetes, Obesity & Metabolism·Clifford J Bailey
Oct 17, 2019·Revista da Associação Médica Brasileira·Mehmet Zahid KocakHaluk Savli
Sep 1, 2019·Journal of Diabetes·Ebaa Al-OzairiReem A Asad
Jan 15, 2020·Journal of Nephrology·Barbara BoninoFrancesca Viazzi
May 3, 2020·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Arrigo F G CiceroClaudio Borghi
Aug 8, 2018·Diabetology & Metabolic Syndrome·Olga LamacchiaSalvatore De Cosmo
Apr 1, 2020·American Journal of Physiology. Renal Physiology·Su Woong JungJu-Young Moon
May 6, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Yau-Jiunn LeeChia-Chang Hsu
May 10, 2017·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Yongze ZhangSunjie Yan
Mar 13, 2017·American Journal of Nephrology·Masanari KuwabaraRichard J Johnson
Jun 23, 2018·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Donald J Weaver
Mar 1, 2019·Journal of Hypertension·Francesca ViazziUNKNOWN AMD-Annals Study Group
Nov 19, 2019·International Journal of Endocrinology·Qing XiongYancheng Xu

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