Serum uric acid and subsequent cognitive performance in patients with pre-existing cardiovascular disease

PloS One
Noa MolshatzkiDavid Tanne

Abstract

High serum uric acid (UA) levels are associated with numerous vascular risk factors, and vascular disease, that predispose patients to cognitive impairment, yet UA is also a major natural antioxidant and higher levels have been linked to slower progression of several neurodegenerative disease. In-order to test the association between UA and subsequent cognitive performance among patients that carry a high vascular burden, UA levels were determined by calorimetric enzymatic tests in a sub-cohort of patients with chronic cardiovascular disease who previously participating in a secondary prevention trial. After an average of 9.8±1.7 years, we assessed cognitive performance (Neurotrax Computerized Cognitive Battery) as well as cerebrovascular reactivity (CVR) and common carotid intima-media thickness (IMT). Among 446 men (mean age 62.3±6.4 yrs) mean UA levels were 5.8±1.1 mg/dL. Adjusted linear regression models revealed that low UA levels (bottom quintile) were associated with poorer cognitive performance. Adjusted differences between the bottom quintile and grouped top UA quintiles were (B coefficient±SE) -4.23±1.28 for global cognitive scores (p = 0.001), -4.69±1.81 for memory scores (p = 0.010), -3.32±1.43 for executive scores ...Continue Reading

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Citations

Feb 2, 2018·Current Opinion in Rheumatology·Augustin LatourtePascal Richette
Feb 28, 2017·Brain and Behavior·Yuzhen XuYuwu Zhao
Apr 23, 2016·Journal of Alzheimer's Disease : JAD·May A BeydounAlan B Zonderman
Sep 19, 2017·Journal of Alzheimer's Disease : JAD·Alexandra M KueiderMadhav Thambisetty

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Software Mentioned

Neurotrax
METRIS
R

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