Serum uric acid in asymptomatic adults is weakly associated with carotid artery FDG uptake but not intima-media thickness.

Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology
Young Seok ChoKyung-Han Lee

Abstract

This study investigated the association of serum uric acid (UA) with carotid fluoro-2-deoxyglucose (FDG) uptake as a marker of inflammatory atherosclerosis. In this cross-sectional retrospective study of 970 otherwise healthy adults, subjects in the greater serum UA quartiles had higher triglyceride (P < .001), lower high-density lipoprotein cholesterol (P < .05), and lower estimated GFR (P < .001). Mean and maximum Target-to-background ratios (TBRs) of carotid FDG uptake measured by positron emission tomography were significantly increased across greater serum UA quartiles (1.35 and 1.57 for Q1, 1.38 and 1.60 for Q2, 1.39 and 1.62 for Q3, and 1.39 and 1.61 for Q4; P = .001 and < .001). Carotid intima-media thickness was not different. Serum UA showed weak but significant correlations with estimated GFR (P < .001), and with mean (P < .001) and maximum carotid TBR (P = .004). Serum UA correlated with mean TBR in male (P = .008) and female subjects (P = .011), in high (≥ 70; P = .015) and low estimated GFR (< 70; P = .035), and in normotensive (P = .001) but not in hypertensive subjects. Elevated serum UA in asymptomatic adults is associated with increased carotid FDG uptake, which suggests a potential role of UA in carotid infla...Continue Reading

References

Jan 1, 1997·Stroke; a Journal of Cerebral Circulation·W H PanH C Chiu
Sep 1, 1997·Metabolism: Clinical and Experimental·A GiacomelloC P Quaratino
Jan 14, 1999·The New England Journal of Medicine·R Ross
Jul 3, 1999·Annals of Internal Medicine·B F CulletonD Levy
Apr 13, 2000·The American Journal of Cardiology·M W Rich
Sep 23, 2000·Nature·A J Lusis
Feb 24, 2005·European Journal of Nuclear Medicine and Molecular Imaging·Michiru Ide, Yutaka Suzuki
Mar 5, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Nobukazu IshizakaMinoru Yamakado
Apr 10, 2007·Journal of the American College of Cardiology·Nobuhiro TaharaTsutomu Imaizumi
Jul 18, 2008·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Su Jin LeeKyung-Han Lee
Sep 12, 2008·The International Journal of Cardiovascular Imaging·Johan WasséliusHans Jacobsson
Oct 24, 2008·The New England Journal of Medicine·Daniel I FeigRichard J Johnson
Jun 3, 2010·The Journal of Clinical Investigation·Alexander So, Bernard Thorens
Apr 27, 2011·Journal of Internal Medicine·F JoshiJ H F Rudd
Nov 19, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Akifumi KushiyamaTomoichiro Asano
Jan 29, 2013·The American Journal of Cardiology·Shaye KivityDavid Olchovsky
Sep 13, 2014·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Su Jin LeeKyung-Han Lee
Feb 14, 2018·Endocrine, Metabolic & Immune Disorders Drug Targets·Giovanni De PergolaMarco Matteo Ciccone

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Related Feeds

Carotid Artery Diseases

Carotid artery disease is a group of pathological conditions of the carotid artery. Discover the latest research on carotid artery disease here.