Serum uric acid is associated with left ventricular hypertrophy independent of serum parathyroid hormone in male cardiac patients

PloS One
Shu-ichi FujitaNobukazu Ishizaka

Abstract

Several studies have shown that serum uric acid (UA) is associated with left ventricular (LV) hypertrophy. Serum levels of parathyroid hormone (PTH), which has bbe shown to be correlated with UA, is also known to be associated with cardiac hypertrophy; however, whether the association between UA and cardiac hypertrophy is independent of PTH remains unknown. We investigated whether the relationship between serum uric acid (UA) and LV hypertrophy is independent of intact PTH and other calcium-phosphate metabolism-related factors in cardiac patients. In a retrospective study, the association between UA and left ventricular mass index was assessed among 116 male cardiac patients (mean age 65 ± 12 years) who were not taking UA lowering drugs. The median UA value was 5.9 mg/dL. Neither age nor body mass index differed significantly among the UA quartile groups. Patients with higher UA levels were more likely to be taking loop diuretics. UA showed a significant correlation with intact PTH (R = 0.34, P<0.001) but not with other calcium-phosphate metabolism-related factors. Linear regression analysis showed that log-transformed UA showed a significant association with left ventricular mass index, and this relationship was found to be si...Continue Reading

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Citations

May 29, 2015·Circulation Journal : Official Journal of the Japanese Circulation Society·Masatoshi MiyamuraNobukazu Ishizaka
Mar 2, 2017·Journal of Hypertension·Elisabeth A LambertJohn B Dixon
Mar 20, 2015·Journal of the American Society of Nephrology : JASN·Marcus E KleberWinfried März
Dec 19, 2017·International Journal of Clinical Practice·Anastazia KeiMoses Elisaf

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Methods Mentioned

BETA
protein binding

Software Mentioned

SPSS

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