Serum uric acid is associated with non-dipping circadian pattern in young patients (30-40 years old) with newly diagnosed essential hypertension

Clinical and Experimental Hypertension : CHE
Francesco GiallauriaCarlo Vigorito

Abstract

We aimed at evaluating the relationship between the circadian blood pressure rhythm and UA level in young patients (30-40 years old) with newly diagnosed essential hypertension. The study included 62 essential hypertensive patients and 29 healthy controls (20 men, 35 ± 3 years) divided into two groups according to 24-hour ABPM results: 30 dippers and 32 nondippers. Nondippers showed significantly higher both serum UA levels compared to dippers and controls (6.1 ± 0.7, 5.2 ± 0.9 and 4.1 ± 0.9 mg/dL, p < 0.001, respectively); and high sensitivity C-reactive protein (hsCRP) (4.1 ± 2.2 mg/L, 3.3 ± 1.9 mg/L, and 1.4 ± 0.9 mg/L, p < 0.001, respectively). After adjusting for age, sex, body mass index, smoking, creatinine levels, hsCRP and comorbidity, multivariate logistic regression analysis revealed an independent association between serum UA levels and nondipper pattern (OR 2.44, 95%CIs 1.4-4.1, p = 0.002). Serum UA is independently associated with nondipper circadian pattern in young patients with newly diagnosed essential hypertension.

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Citations

Mar 18, 2020·American Journal of Hypertension·Laura G Sanchez-LozadaRichard J Johnson
Feb 14, 2017·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Yang WangJian-Jun Mu
Jan 6, 2021·The Journal of Clinical Hypertension·Kazuomi KarioIchiro Hisatome
Nov 16, 2021·Clinical Hypertension·Chavalit ChotruangnapaWeranuj Roubsanthisuk

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