Serum uric acid level and its association with motor subtypes and non-motor symptoms in early Parkinson's disease: PALS study

Parkinsonism & Related Disorders
Xinxin HuangLouis Chew-Seng Tan

Abstract

Uric acid has been found to be potentially neuroprotective in Parkinson's disease (PD). We investigated the relationship between serum uric acid levels and both motor and non-motor features in a prospective early PD cohort study. Fasting serum uric acid levels were measured from 125 early PD patients. Demographic, clinical characteristics, motor and non-motor assessments were performed. Patients were categorized into three motor subtypes: tremor-dominant (TD), postural instability/gait difficulty (PIGD), and mixed. Non-motor symptoms were classified as present or absent based on the appropriate cut-offs for each non-motor instrument. Most patients had TD (n = 51, 40.8%) and mixed (n = 63, 50.4%) motor subtypes, while a minority had PIGD (n = 11, 8.8%) motor subtype. The mean serum uric acid levels were significantly different between the three motor subtypes (p = 0.0106), with the mixed subtype having the lowest serum uric acid levels. Using the TD subtype as reference, patients with higher serum uric acid levels were less likely to have the mixed (OR = 0.684; p = 0.0312) subtype as opposed to the TD subtype. Uric acid levels were not significantly different between the TD and PIGD subtypes. For non-motor symptoms, higher serum...Continue Reading

Citations

Oct 23, 2018·Movement Disorders : Official Journal of the Movement Disorder Society·Xinxin HuangLouis Chew-Seng Tan
Aug 1, 2018·Nutrients·Claudio TanaTiziana Meschi
Mar 25, 2019·Frontiers in Neurology·Tino PrellJulian Grosskreutz
May 24, 2020·Journal of Parkinson's Disease·Daniel J van WamelenK Ray Chaudhuri
Jul 18, 2020·International Journal of Endocrinology·Xiaocong YaoZhongxin Zhu
Nov 18, 2018·International Journal of Molecular Sciences·Mercedes Garcia-GilMaria Grazia Tozzi
Aug 26, 2019·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Y-S OhK-S Lee
Apr 23, 2020·International Journal of Molecular Sciences·Lisa MészárosJürgen Winkler
Jun 1, 2020·Parkinsonism & Related Disorders·Yang Hyun LeePhil Hyu Lee
Mar 16, 2021·Frontiers in Aging Neuroscience·Zhike ZhouMei Zhao
Nov 13, 2018·EBioMedicine·Xiqun ChenUNKNOWN Parkinson Study Group (PSG) The Safety of Urate Elevation in Parkinson's Disease (SURE-PD) investigators
May 16, 2021·European Radiology·Ling Ling ChanNicole C H Keong
Oct 9, 2019·Aging and Disease·Elizabeth Qian, Yue Huang
Aug 19, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Xiaoxue ShiShiyu Hu
Jan 1, 2022·Current Rheumatology Reports·Augustin LatourtePascal Richette

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