Serum uric acid levels and mortality in the Japanese population: the Yamagata (Takahata) study

Clinical and Experimental Nephrology
Keita KameiIsao Kubota

Abstract

Serum uric acid level is regulated by gender, dietary habit, genetic predisposition, and renal function, and is associated with the development of renal and cardiovascular diseases. This study prospectively investigated the association between serum uric acid levels and mortality in a community-based population. Three thousand four hundred and eighty-seven subjects regardless of the antihyperuricemic medication (45 % male; mean age 62 years old) from the Takahata town in Japan participated in this study and were followed up for 8 years (median 7.5 years). We examined the association between serum uric acid levels at baseline and the all-cause and cardiovascular mortality, respectively, in this population. One hundred seventy-nine subjects died during the follow-up period, with 49 deaths attributed to cardiovascular causes. Kaplan-Meier analysis revealed that the all-cause mortality was significantly higher along with the increase in serum uric acid levels at baseline among female (Log-rank P < 0.01), but not male subjects (P = 0.97). Cox-proportional hazard model analysis with adjustment for possible confounders including age, renal function, and comorbidities revealed that hyperuricemia (uric acid ≥7.0 mg/dL) was an independen...Continue Reading

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Citations

May 14, 2016·Journal of Atherosclerosis and Thrombosis·Hirohito Metoki
Jan 13, 2018·Acta Diabetologica·Aldo BonaventuraRenzo Cordera
Jul 21, 2020·Journal of Korean Medical Science·Kipyo KimJung Hwan Park
Jul 28, 2020·Clinical and Experimental Nephrology·Shigeatsu HashimotoUNKNOWN Fukushima Health Management Survey Group
Jul 29, 2021·Chinese Medical Journal·Dong-Yuan ChangMing-Hui Zhao

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