PMID: 15222691Jun 30, 2004Paper

Serum uric acid levels in optic neuritis

Multiple Sclerosis : Clinical and Laboratory Research
C M KnappI Gottlob

Abstract

Uric acid, an antioxidant, is reduced in multiple sclerosis (MS). Patients with gout have a reduced incidence of MS. Optic neuritis (ON), often the first manifestation of MS, is not known to be associated with reduced uric acid. Patients with recent onset of ON were investigated to determine whether uric acid levels were reduced at presentation. Twenty-one patients with ON were included, 17 females and 4 males. The mean (SD) serum uric acid in the ON female group was 184.4 ( +/-55.1) micromol/L (range, 116-309 micromol/L), whilst in the control group it was 235.2 (+/- 50.2) micromol/L (range, 172-381 micromol/L). The difference was statistically significant (chi2 = 8.93, P = 0.003). In the small male cohort, mean (SD) serum uric acid was 305 (+/- 52.1) micromol/L, whilst in the control group it was 328 (+/- 80.4) micromol/L. These differences were not statistically significant. Reduced antioxidant reserve is possibly an early pathogenic mechanism in inflammatory demyelination, and raises the possibility that low uric acid levels could be an indicator of disease activity. Since optic neuropathies of other causes were not investigated, future research needs to determine whether low uric acid represents a unique feature of optic n...Continue Reading

References

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Citations

May 27, 2009·Journal of Neurology·Jennifer MassaA Ascherio
Jun 6, 2009·Clinical Chemistry and Laboratory Medicine : CCLM·Irena DujmovicJelena Drulovic
Aug 2, 2011·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·F PengX Zhong
Dec 30, 2015·Current Neurology and Neuroscience Reports·Laura LlullÁngel Chamorro
Mar 4, 2008·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A L GuerreroC Alcázar
Jan 23, 2010·Journal of Neurology·Fuhua PengYongqiang Dai
Feb 13, 2015·Journal of Neurology·Marcello MocciaVincenzo Brescia Morra
May 12, 2006·Neurological Research·Marcus Koch, Jacques De Keyser
Dec 4, 2010·Antioxidants & Redox Signaling·Jeffrey K Yao, Matcheri S Keshavan
Apr 23, 2016·Journal of Alzheimer's Disease : JAD·May A BeydounAlan B Zonderman
Sep 25, 2007·The Journal of Pharmacology and Experimental Therapeutics·Melinda K Kutzing, Bonnie L Firestein
Nov 24, 2006·Vojnosanitetski pregled. Military-medical and pharmaceutical review·Goran Toncev
Oct 16, 2010·Biomarkers in Medicine·Sara CiprianiMichael A Schwarzschild
Oct 6, 2005·Clinical Neurology and Neurosurgery·M RentzosD Vassilopoulos
Jul 28, 2009·Clinical Neurology and Neurosurgery·Elisabeth AndreadouDemetrios Vassilopoulos

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