Serum VEGF and PGF may be significant markers in prediction of severity of preeclampsia

The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Emel KurtogluAyse Zehra Ozdemir

Abstract

The aim of this study evaluate the value of vascular endothelial growth factor (VEGF) and placental growth factor (PGF) serum levels in prediction of preeclampsia, severity and onset time of the disease. Twenty five placentas of pregnant women diagnosed with preeclampsia (15 severe preeclampsia, 10 mild preeclampsia) and peripheral venous blood samples were collected. The placental and serum levels of VEGF and PGF were measured. VEGF level was significantly higher in cases and the optimal cut-off point was calculated as 600.5 to differentiate the cases and the controls, with 64% sensitivity and 100% specificity. There was a significant increase in median serum level of VEGF in severe cases compared to the mild cases and the controls. The optimal cut-off point for VEGF was calculated as 673.5 to differentiate mild and severe cases, with 93.3% sensitivity and 90% specificity. Whereas, PGF was significantly lower in severe cases than that in the mild cases and controls. The optimal cut-off point for PGF was calculated as 16.1 to differentiate mild and severe cases, with 66.7% sensitivity and 100% specificity. VEGF and PGF may be significant markers in prediction of severity of preeclampsia, and VEGF may also be valuable in predict...Continue Reading

References

Nov 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·R L Kendall, K A Thomas
Oct 16, 1999·British Journal of Obstetrics and Gynaecology·A ReuvekampA J Duits
May 29, 2000·BJOG : an International Journal of Obstetrics and Gynaecology·L A SimmonsR W Jeremy
Dec 20, 2000·American Journal of Obstetrics and Gynecology·J C LivingstonB M Sibai
Feb 24, 2001·Lancet·J M Roberts, D W Cooper
Jun 14, 2002·Placenta·J M Roberts, K Y Lain
Jan 28, 2003·American Journal of Obstetrics and Gynecology·Robert N TaylorRobyn A North
Feb 7, 2004·The New England Journal of Medicine·Richard J LevineS Ananth Karumanchi
Jun 17, 2004·BJOG : an International Journal of Obstetrics and Gynaecology·Eleonora SgambatiEnzo Brizzi
Feb 7, 2006·American Journal of Obstetrics and Gynecology·Hisashi MasuyamaYuji Hiramatrsu
Feb 23, 2008·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Patrícia Gonçalves TeixeiraCezar Alencar de Lima Rezende
Jun 19, 2012·American Journal of Obstetrics and Gynecology·Samantha WeedSindhu K Srinivas
Feb 12, 2013·Current Hypertension Reports·Vesna D Garovic, Phyllis August

❮ Previous
Next ❯

Citations

Jan 25, 2017·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Roberto RomeroTinnakorn Chaiworapongsa
Mar 3, 2018·Molecular and Cellular Biochemistry·Zhonglin XiaoXiujun Fan
Apr 9, 2020·International Journal of Molecular Sciences·Miguel A OrtegaNatalio García-Honduvilla
Jun 15, 2016·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Yasemin ÇekmezGürkan Kıran
Jul 5, 2017·Journal of Perinatal Medicine·Maya A DeyssenrothJia Chen
Jul 10, 2020·Curēus·Andong HeRuiman Li

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Related Papers

Eastern Mediterranean Health Journal = La Revue De Santé De La Méditerranée Orientale = Al-Majallah Al-ṣiḥḥīyah Li-sharq Al-mutawassiṭ
R A K Mahmound, M Abdel-Raouf
Zeitschrift für Geburtshilfe und Neonatologie
Stefanie BussenJ Dietl
Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy
Adi Y WeintraubMahmoud Huleihel
© 2021 Meta ULC. All rights reserved