Serum VEGF levels in the early diagnosis and severity assessment of non-small cell lung cancer

Journal of Cancer
Yanzhen LaiWanli Liu

Abstract

Background: Effective biomarkers are essential to the differential diagnosis and severity assessment of non-small cell lung cancer (NSCLC). This study explored the use of the serum vascular endothelial growth factor (VEGF) levels as a biomarker with the aim of achieving better management of NSCLC. Methods: Serum VEGF levels were assayed via enzyme-linked immunosorbent assay in 180 patients with NSCLC, 136 patients with benign pulmonary nodules, and 119 healthy controls. We additionally detected the serum concentration of three traditional biomarkers-carcinoembryonic antigen (CEA), cancer antigen (CA)-125, and cytokeratin 19 fragments (Cyfra 21-1)-to comparatively evaluate the efficiency and diagnostic value of VEGF in patients with NSCLC. We further evaluated the relationship between serum VEGF levels and clinicopathologic parameters. VEGF levels were compared between pro- and post-surgical patients using the Wilcoxon matched-pairs signed-rank test. DNA was isolated from the primary tumors. EGFR mutations were detected by Scorpions amplification refractory mutation system (ARMS). Results: Patients with NSCLC had significantly higher serum concentration of VEGF, compared to those with benign pulmonary nodules and healthy control...Continue Reading

Citations

Aug 23, 2019·The International Journal of Biological Markers·Lei FuPengjun Zhang
Jun 8, 2021·Cancer Biomarkers : Section a of Disease Markers·Ganbiao WangYongxiang Li
Aug 25, 2021·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Florentin SpäthRoel Vermeulen
Jul 22, 2020·Combinatorial Chemistry & High Throughput Screening·Zheng DongShuai Dang

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Methods Mentioned

BETA
bronchoalveolar lavage
PCR
electrophoresis
enzyme-linked immunosorbent assay
ELISA
imaging techniques

Software Mentioned

SDS2
SPSS

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