Serum vitamin A and beta-carotene levels in pregnant women infected with human immunodeficiency virus-1

Obstetrics and Gynecology
W PhuapraditN Lerdvuthisopon

Abstract

To determine if low levels of serum vitamin A and beta-carotene are present in pregnant women with human immunodeficiency virus-1 (HIV-1) infection. Serum concentrations of vitamin A and beta-carotene were measured in 74 pregnant women seropositive for HIV-1 infection (17 with CD4 count below 200 cells/microliter) and in 148 pregnant seronegative controls in the first trimester. Comparisons were made between groups stratified by CD4 count. Compared with controls, women with HIV-1 infection and CD4 count below 200 cells/microliter exhibited 37% lower mean serum vitamin A levels (0.820 versus 1.308 micromol/L, P < .001) and 37% lower mean serum beta-carotene levels (1.486 versus 2.362 micromol/L, P < .001). Mean maternal age, parity, gestational age, hemoglobin levels, and body mass index at entry into the study did not differ significantly between the control and HIV-1 infection groups. In addition, serum vitamin A levels correlated significantly with the percentage of CD4 lymphocytes (r = 0.589, P < .001), CD4 count (r = 0.772, P < .001), and CD4 to CD8 ratio (r = 0.593, P < .001). Serum beta-carotene levels correlated with the percentage of CD4 lymphocytes (r = 0.407, P < .001), CD4 count (r = 0.614, P < .001), and CD4 to CD8 ...Continue Reading

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Citations

Aug 6, 1999·The British Journal of Nutrition·R D Semba, A M Tang
May 21, 2005·AIDS·Alice M TangChristine Wanke
Sep 1, 1999·The Journal of Obstetrics and Gynaecology Research·W PhuapraditO Puchaiwatananon
Oct 7, 1998·The Australian & New Zealand Journal of Obstetrics & Gynaecology·W Phuapradit
Jun 1, 1997·American Journal of Public Health·P Zimmer, C Garza
Nov 3, 2009·American Journal of Obstetrics and Gynecology·Agustín Conde-Agudelo, Roberto Romero
Aug 29, 2003·Journal of the International Association of Physicians in AIDS Care : JIAPAC·Neera Singhal, James Austin
Mar 17, 2007·International Journal of STD & AIDS·Jared M BaetenJoan K Kreiss
Jun 3, 2000·Journal of Acquired Immune Deficiency Syndromes : JAIDS·A M TangD Vlahov
May 25, 2006·European Journal of Clinical Nutrition·J AustinUNKNOWN CTN 091/CRIT Cartenoids Study Group
Dec 29, 2000·Journal of Acquired Immune Deficiency Syndromes : JAIDS·A M Tang, E Smit
May 11, 2007·The American Journal of Clinical Nutrition·Beth C TohillAnn Duerr

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