Serum vitamin D and change in lipid levels over 5 y: The Atherosclerosis Risk in Communities study

Nutrition
Kamil F FaridiErin D Michos

Abstract

Deficiency of 25-hydroxyvitamin D (25[OH]D) is associated with increased risk for cardiovascular disease, perhaps mediated through dyslipidemia. Deficient 25(OH)D is cross-sectionally associated with dyslipidemia, but little is known about longitudinal lipid changes. The aim of this study was to determine the relationship of 25(OH)D deficiency to longitudinal lipid changes and risk for incident dyslipidemia. This was a longitudinal community-based study of 13 039 participants from the ARIC (Atherosclerosis Risk in Communities) study who had 25(OH)D and lipids measured at baseline (1990-1992) and lipids remeasured in 1993 to 1994 and 1996 to 1998. Mixed-effect models were used to assess the association of 25(OH)D and lipid trends after adjusting for clinical characteristics and for baseline or incident use of lipid-lowering therapy. Risk for incident dyslipidemia was determined for those without baseline dyslipidemia. Baseline mean ± SD age was 57 ± 6 y and 25(OH)D was 24 ± 9 ng/mL. Participants were 57% women, 24% black. Over a mean follow-up of 5.2 y, the fully adjusted average differences (95% confidence interval [CI]) comparing deficient (<20 ng/mL) to optimal (≥30 ng/mL) 25(OH)D were: total cholesterol (TC) -2.40 mg/dL (-4....Continue Reading

Citations

Jun 10, 2020·Metabolic Syndrome and Related Disorders·Karine L Curvello-SilvaCarla Daltro
Jun 5, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Fatemeh Saheb Sharif-AskariNabil Sulaiman
Jan 30, 2021·Journal of the American College of Cardiology·Erin D MichosLawrence J Appel
Jan 7, 2021·Global Pediatric Health·Mohan KumaratneJasmine Cisneros

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