PMID: 2498490Jun 1, 1989Paper

Serum vitamin D metabolites in very low birth weight infants with and without rickets and fractures

The Journal of Pediatrics
W W KooR C Tsang

Abstract

Seventy-one very low birth weight (less than or equal to 1500 gm) infants were studied to determine the sequential changes in serum vitamin D metabolite concentrations between infants with and without radiographically documented rickets, fractures, or both (R/F). Usual intake of vitamin D included 20 IU/kg/day from parenteral nutrition or 400 IU/day supplementation with enteral feeding. Radiographs of both forearms and serum samples were obtained at 3, 6, 9, and 12 months. Twenty-two infants had R/F. At 3 months, significantly lower mean (+/- SEM) serum phosphorus levels (4.5 +/- 0.4 vs 6.1 +/- 0.2 mg/dl), higher 1,25-dihydroxyvitamin D (1,25-[OH]2D) concentrations (96 +/- 5 vs 77 +/- 4 pg/ml), and higher free 1,25-(OH)2D index (1,25-[OH]2D:vitamin D binding protein ratio; 5.2 +/- 0.3 x 10(5) vs 4.0 +/- 0.2 x 10(5] were found in the R/F group. These values returned to normal and were similar between groups on subsequent measurements. Serum calcium, magnesium, and 25-hydroxyvitamin D (25-OHD) concentrations were normal and similar between groups. In both groups, serum vitamin D binding concentrations increased initially but remained stable and normal beyond 6 months. We conclude that in very low birth weight infants with R/F, th...Continue Reading

References

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Citations

Jul 25, 2013·Current Osteoporosis Reports·Winston Koo, Nitin Walyat
Jan 1, 1997·Nutrition Research Reviews·H J Powers
Aug 1, 1995·Acta Paediatrica Japonica; Overseas Edition·E YenerS Mir
Aug 24, 2002·Archives of Disease in Childhood. Fetal and Neonatal Edition·J FaerkK F Michaelsen
Mar 14, 2008·Journal of Perinatology : Official Journal of the California Perinatal Association·L J Moyer-MileurG M Chan
Jul 18, 2008·Journal of Perinatology : Official Journal of the California Perinatal Association·C M VignochiL H Canani
Oct 1, 1995·The Journal of Pediatrics·L Moyer-MileurG M Chan
Nov 9, 2010·Advances in Pediatrics·Melissa K Egge, Carol D Berkowitz
Jan 7, 2000·Pediatric Research·J FaerkK F Michaelsen
Jul 1, 1992·JPEN. Journal of Parenteral and Enteral Nutrition·W W Koo
Jun 26, 2012·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Vincent W VanekUNKNOWN American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.) Board of Directors
Aug 18, 2004·Pediatrics International : Official Journal of the Japan Pediatric Society·Yasushi NakoAkihiro Morikawa
Dec 31, 1997·Endocrine Reviews·C S Kovacs, H M Kronenberg
Oct 1, 1991·Journal of the American College of Nutrition·W W Koo, R C Tsang
Aug 1, 1996·Annals of Medicine·M C BackströmR Mäki

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