Serum vitamin D receptor (VDR) levels as a potential diagnostic marker for colorectal cancer

Saudi Journal of Biological Sciences
Ayat B Al-GhafariHuda A Al Doghaither

Abstract

Colorectal cancer (CRC) is one of the leading causes of mortality and morbidity worldwide, and there has been a significant increase in the incidence of CRC in recent decades. Therefore, there is an urgent need to identify blood biomarkers that can be used for early diagnosis. It is not yet clear whether the level of vitamin D and its receptor, vitamin D receptor (VDR), in the blood are helpful factors in the diagnosis of CRC. Therefore, the study focuses on determining the VDR serum level's contribution and other chemical parameters to the risk of CRC. A total of 189 Saudi participants (66 CRC patients and 123 control patients) aged 20-80 years old were enrolled in this case-control study. A serum sample was collected from each participant, and the levels of VDR and other bone profile tests were determined using ELISA or chemiluminescent assays. P values < 0.05 were considered statistically significant. The results showed a highly significant reduction in the levels of total vitamin D (P < 0.0001), VDR (P < 0.0001), vitamin D3 (P < 0.05), and calcium (P < 0.0001) in the serum of CRC patients compared to the controls. However, the alkaline phosphatase level was higher in CRC patients compared to the controls (P < 0.0001). None ...Continue Reading

Citations

Aug 24, 2020·European Journal of Medicinal Chemistry·Jingxuan ChenJianjun Chen
Dec 24, 2020·Critical Reviews in Food Science and Nutrition·Mónica R Meza-MezaUlises de la Cruz-Mosso

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